Comparing Classic High-Frequency rTMS and Deep rTMS Treatments for Resistant Depression Randomized Study Using Different Coils with Standard Therapies

What this Trial Is About

Researchers are evaluating the effectiveness of two different types of repetitive transcranial magnetic stimulation rTMS treatments to manage treatment-resistant depressive disorder. The study aims to show whether deep rTMS, using an H1-shaped coil, is more efficient than classic high-frequency rTMS with a conventional 8-shaped coil. Participants are adults diagnosed with recurrent or isolated depressive episodes according to DSM IV criteria and who have not changed their antidepressant treatment for at least three weeks. Participants will be randomly assigned to one of two treatment groups. One group will receive classic rTMS with the 8-shaped coil combined with standard therapy, while the other group will receive deep rTMS using the H1-shaped coil and standard therapies. Both groups will undergo 20 rTMS sessions scheduled as five sessions per week. Following treatment, there are three follow-up visits planned at 30, 60, and 90 days. During the study, participants will be monitored for changes in their depression symptoms, primarily measured by the Montgomery and sberg Depression Rating Scale MADRS at Day 60, focusing on a 50% improvement in score. Regular assessments and follow-ups will allow researchers to compare the effects of the two rTMS methods. The total duration of participation includes treatment sessions and follow-up visits over approximately three months.

Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment