Actively Recruiting
Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment
Led by Centre Hospitalier Henri Laborit · Updated on 2026-01-13
152
Participants Needed
1
Research Sites
362 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main objective is to demonstrate that dTMS is more efficient than high frequency rTMS with a conventional coil. The patient will receive treatment arm A or B : Arm A : classic rTMS treatment (use of the 8-shaped coil) and standard therapy Arm B: treatment with deep rTMS (use of the H-shaped coil (helmet)) and standard therapies. 20 rTMS sessions are planned (5 sessions per week) and 3 follow-up visits : at Day 30, Day 60 and Day 90.
CONDITIONS
Official Title
Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Volunteer subjects over 18 years old
- Signed free and informed consent
- Diagnosis of characterized depressive episode, recurrent or isolated, according to DSM IV criteria
- Stable antidepressant treatment for at least 3 weeks
- MADRS score of 21 or higher
- Affiliation to a social security system
You will not qualify if you...
- Depression with psychotic features
- Co-morbid DSM IV axis I diagnoses such as schizophrenia or substance dependence
- Previous electroconvulsive therapy for current episode with no response
- Hospitalization under duress or legal protection measures
- High suicide risk (MADRS item 10 score greater than 4) without hospitalization
- Contraindications to MRI or rTMS including history of seizures, neurological or neurosurgical disorders, or implanted metallic devices
- Pregnancy
- Participation in another interventional study at the same time
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Centre Hospitalier Henri Laborit
Poitiers, France
Actively Recruiting
Research Team
G
Ghina HARIKA-GERMANEAU, Dr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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