Study of Estrogen Effects on Muscle Growth and Function With 12 Weeks of Exercise in Postmenopausal Women

What this Trial Is About

Researchers are investigating how the decline in oestrogen levels during menopause affects muscle mass and function in postmenopausal women. The study, called HER-MUSCLE, aims to understand how oestrogen supports muscle growth, especially during exercise, to inform targeted therapies that may improve physical health and function in this group. Participants will be randomly assigned to receive either transdermal oestrogen Estrogel or a placebo while undergoing a supervised 12-week exercise program that includes strength and cardiovascular training. The trial uses advanced molecular techniques to study muscle cells and assesses mitochondrial function through magnetic resonance spectroscopy to explore how oestrogen may preserve muscle and energy function. During the study, participants will have their muscle mass, strength, body composition, and cardiovascular fitness measured at 12 weeks. Researchers will also examine muscle tissue for cellular and protein changes, monitor blood pressure, blood volume, and other physical functions, and collect questionnaire data. The study includes safety monitoring and aims to provide insights into managing muscle loss in postmenopausal women.

Effects of Estrogen on Muscle Gain During 12-weeks of Exercise in Post-menopausal Women