Study on Effects of Exogenous Ketone Supplement on Brain Energy Use and Thinking Speed in Older Adults with Prediabetes

What this Trial Is About

Researchers are investigating whether older adults aged 60 to 75 with prediabetes, but no diagnosed cognitive impairment, show early changes in brain energy use and slower thinking speed compared to those with normal blood sugar levels. The study also evaluates if a single dose of an exogenous ketone supplement can improve brain energy use and cognitive processing speed. This research aims to better understand the link between metabolic dysfunction and early brain changes that may increase dementia risk. Participants receive either a single oral dose of a ketone monoester supplement or a taste- and appearance-matched placebo during two separate visits within four weeks. Brain imaging using fluorodeoxyglucose F18 positron emission tomography combined with magnetic resonance imaging 18FDG-PETMRI is performed after ingestion while participants complete a cognitive processing speed task. This crossover design allows comparison of brain glucose uptake and cognitive performance between ketone and placebo conditions. During the study, participants undergo metabolic testing to determine glucose regulation status and brain imaging sessions with cognitive testing to measure processing speed and brain activity. Researchers assess changes in regional brain glucose uptake and cognitive processing speed as primary outcomes. Safety and tolerance of the supplement are monitored, and participation involves two study visits within one month. The findings will help clarify if ketone supplementation can temporarily support brain function in older adults at risk for cognitive decline.

Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?