Effects of fatigue and chewing training on maximal bite force and endurance.
S Kiliaridis, M G Tzakis, G E Carlsson
https://pubmed.ncbi.nlm.nih.gov/7709901/Actively Recruiting
Led by UConn Health · Updated on 2026-07-24
20
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are investigating whether chewing a standardized hard gum for four weeks can cause measurable changes in facial soft tissue shape in healthy adults. The study focuses on adults aged 20 to 40 and uses advanced three-dimensional facial imaging to assess facial morphology. This pilot trial aims to provide scientific evidence on the effects of masticatory muscle activity on facial appearance, particularly regarding facial definition and jawline shape. Participants will follow a prescribed chewing routine using a hard gum called Jawliner, chewing every other day for about 16 minutes per session. The chewing sessions involve controlled pace and alternating sides of the mouth to ensure consistent muscle activity. Facial images will be taken before the chewing starts, immediately after the four-week chewing period, and again after a 4 to 5-week washout phase. During the study, participants will attend three imaging visits for 3D facial scans and complete questionnaires about muscle fatigue, soreness, oral behaviors, and symptoms related to temporomandibular disorders. Researchers will analyze changes in facial soft tissue using surface mapping, heatmaps, and morphometric measures. Additional assessments include monitoring body weight, height, and various symptom questionnaires. The study lasts about 8 to 9 weeks including the washout period, with safety and adherence monitored throughout.
CONDITIONS
Effects of Hard Gum Chewing on Facial Soft Tissue Morphology
F
Flavio Uribe (Chair, Depto Orthodontics; UConn School of dental medic
G
Georgiana Defilio
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UConn Health
Lead Sponsor
Charles Burstone Foundation
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Structured Hard Gum Chewing | Usual Chewing (No Protocol) |
|---|---|---|
| What it is | A structured protocol where participants chew a standardized hard chewing gum for defined sessions over 4 weeks. | Regular mastication without structured chewing routines, reflecting everyday chewing habits. |
| Role in trial | Studied for its effects on facial soft tissue and muscle morphology. | Serves as the reference for natural chewing performance and facial structure. |
| Primary use | Investigational use to assess its impact on facial muscle and soft tissue morphology, bite force, and functional outcomes. | Everyday mastication maintains baseline facial muscle activity and soft tissue structure. |
| How it is given or performed | Every other day, participants chew hard gum using controlled timing and force, alternating sides for two blocks of 8 minutes each. | No structured regimen; participants engage in chewing during regular eating habits. |
| Evidence status | Currently being studied for effects on facial morphology and bite force; results not yet established in clinical trials. | Serves as a baseline in published chewing training studies; facial muscle effects are established as reference but not as an investigational protocol. |
| Important limitations | Limited to healthy adults, short intervention period, and excludes individuals with facial asymmetry, malocclusion, or temporomandibular disorder history. | Does not represent structured intervention or effects beyond habitual mastication; background chewing habits may vary individually. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit
Duration - 4 weeks
Participants chew a standardized hard gum every other day for 4 weeks following a set chewing protocol lasting about 16 minutes per session.
Regular chewing sessions every other day
Duration - 4 to 5 weeks
Participants stop chewing the gum and undergo follow-up assessments to observe any lasting facial changes after 4 to 5 weeks.
Follow-up visits for facial imaging and questionnaires
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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S Kiliaridis, M G Tzakis, G E Carlsson
https://pubmed.ncbi.nlm.nih.gov/7709901/Manami Shirai, Nobuhiko Kawai, Natsuko Hichijo...
https://pubmed.ncbi.nlm.nih.gov/29744215/M G Tzakis, S Kiliaridis, G E Carlsson
https://pubmed.ncbi.nlm.nih.gov/2609943/M G Tzakis, S Kiliaridis, G E Carlsson
https://pubmed.ncbi.nlm.nih.gov/8133387/UConn Health
Lead Sponsor
Charles Burstone Foundation
Collaborating Sponsor