Study of a Healthy Nordic Diet to Slow Atherosclerosis in People with Coronary Heart Disease Ages 50 to 80

What this Trial Is About

Researchers are studying how a healthy Nordic diet HND may affect atherosclerosis and coronary heart disease CHD. This trial focuses on whether the HND can reduce plaque volume, coronary artery calcification, and plaque inflammation in people with CHD. The study also explores if changes in gut microbiota relate to plaque progression and whether individual metabolic profiles can predict diet responses. This randomized, double-blinded trial includes 150 patients with a history of myocardial infarction or chronic coronary syndrome, aged 50 to 80 years. Participants are assigned to one of two groups one receives dietary advice plus key Nordic foods rich in whole grains and unsaturated fats, while the other receives usual care dietary advice as per national guidelines. The intervention lasts 18 months, with dietary intake monitored through food records and biomarkers at multiple points. Coronary plaque and composition are assessed using advanced CT angiography at the start and end of the study. Blood glucose and heart activity are tracked using wearable monitors. Throughout the study, researchers will evaluate changes in coronary plaque volume as the primary outcome, along with plaque composition, inflammation, coronary artery calcium, ectopic fat, blood lipids, blood pressure, and cardiovascular events. They will also analyze gut microbiota and metabolic profiles to identify responders to the diet. Follow-up includes monitoring these markers up to 30 months. This comprehensive approach aims to provide new insights into diets role in managing coronary artery disease.

Effects of a Healthy Nordic Diet on Atherosclerosis in Patients with Coronary Heart Disease