Actively Recruiting
Effects of Low-level Laser Therapy on Soft and Hard Tissue Healing After Impacted Mandibular Third Molar Extraction
Led by University of Medicine and Pharmacy at Ho Chi Minh City · Updated on 2025-11-28
22
Participants Needed
1
Research Sites
17 weeks
Total Duration
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AI-Summary
What this Trial Is About
This research aims to evaluate the effects of low-level laser therapy (LLLT) on healing after surgical removal of impacted lower third molars, commonly known as wisdom teeth. Impacted lower third molar extraction is a frequent dental procedure that can cause complications such as swelling, pain, jaw tightness, and bone or gum problems after surgery. While various grafting materials have been used to improve healing, they can be costly, time-consuming, and carry risks of infection. LLLT is a safe, non-invasive approach that influences cell metabolism and has shown promising results in reducing post-surgery discomfort and promoting healing, but more scientific evidence is needed in humans. In this study, patients will have both lower impacted third molars removed. One side will not receive active laser therapy, serving as a control, while the other side will receive seven sessions of low-level laser therapy. These sessions occur on the day of surgery and then on days 1, 3, 7, 14, 21, and 28 post-surgery. This design allows comparison of healing between treated and untreated sites within the same patient. Participants will be monitored for wound healing scores on days 3, 7, and 30 after surgery. Bone healing will be assessed by measuring new bone density and changes in the alveolar crest level next to the second lower molar on the day of surgery, and again at one and three months. The study includes healthy adult patients with impacted lower third molars and involves randomized, double-blind procedures to evaluate the benefits of low-level laser therapy over a follow-up period of three months.
CONDITIONS
Brief Title
Effects of Low-level Laser Therapy on Soft and Hard Tissue Healing After Impacted Mandibular Third Molar Extraction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy patients aged 18 years or older
- Have impacted lower third molars on both sides of the lower jaw
- Both teeth are indicated for extraction
- Teeth conditions are the same on both sides
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 4 weeks
Participants undergo impacted mandibular third molar extraction surgery and receive low level laser therapy (LLLT) on one side. LLLT sessions occur on the day of surgery and at 1, 3, 7, 14, 21, and 28 days after surgery.
7 visits for LLLT sessions (in-person)
Duration - Up to 3 months
Participants are monitored to assess wound healing, bone density, and alveolar crest level at specified time points after surgery.
Visits on day 3, day 7, day 30, 1 month, and 3 months after surgery
Trial Site Locations
Total: 1 location
1
University of medicine and pharmacy at Ho Chi Minh city
Ho Chi Minh City, Vietnam, 7000000
Actively Recruiting
Research Team
H
Hiep Hoang Ngoc Nguyen, Doctor of Dental Surgery
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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