Actively Recruiting
A Randomized, Double-Blind, Placebo-Controlled Study of ABKefir Capsules for Adults With Functional Constipation
Led by Chung Shan Medical University · Updated on 2026-01-02
165
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What This Trial Is About
Researchers are studying the effects of ABKefir probiotics on adults with functional constipation to see if taking one capsule daily can improve constipation symptoms. This randomized, double-blind, placebo-controlled clinical trial involves 165 adults aged 18 to 75 who meet specific criteria for functional constipation. The trial aims to assess changes in constipation symptoms over an eight-week period. Participants will be randomly assigned to one of three groups a placebo group, a low-dose ABKefir group taking 5 x 109 CFU per capsule, or a high-dose ABKefir group taking 1 x 1010 CFU per capsule. For the first four weeks, subjects take one capsule daily within 30 minutes after breakfast. After this period, there is a four-week follow-up phase without supplementation. Throughout the study, participants will have assessments at the start, week 4, and week 8, including body measurements, defecation questionnaires, food records, and collections of feces and blood samples. Researchers will measure changes in constipation symptoms from baseline at weeks 4 and 8 to evaluate the impact of the probiotic treatment.
CONDITIONS
Brief Title
Effects of Probiotics on Symptoms of Constipation in Adults With Functional Constipation
Research Team
C
Chin-Lin Hsu, Professor
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