Study of Heart Function and Effects of Lung Disease Treatments Using Cardiac MRI in Adults with COPD, Asthma, or Pulmonary Fibrosis

What this Trial Is About

Researchers are investigating the heart and lung interactions in people with chronic lung diseases such as COPD, bronchial asthma, and pulmonary fibrosis. The study aims to understand how these lung diseases and their treatments affect heart function, focusing especially on the left heart, which has been less studied. Cardiac MRI, a detailed imaging technique, will be used to assess heart function, structure, and signs of inflammation or damage, alongside echocardiography for additional heart evaluations. Participants with chronic lung diseases will undergo cardiac MRI and echocardiography before starting treatment and again three months after treatment begins. The study includes different patient groups based on their lung disease and planned treatments, including inhaled corticosteroids, long-term oxygen therapy, roflumilast, antibody therapy, and antifibrotic therapy. Researchers will evaluate heart volumes, myocardial fibrosis or edema, pulmonary artery function, and left ventricular strain using these imaging methods. During the study, participants will have heart and lung function assessed through cardiac MRI and echocardiography at the start and after three months of treatment. Researchers will measure heart volume, blood flow in lung vessels, heart muscle strain, and any signs of heart tissue damage. These assessments will help identify relationships between lung function and heart health. The total study period for each participant is about three to six months, with ongoing monitoring of cardiovascular changes after treatment starts.

Effects of Pulmonary Diseases and Their Treatment on Cardiac Function