Study on Using Rectal Indomethacin Suppository to Prevent Catheter-Related Bladder Discomfort After Laparoscopic Radical Prostatectomy

What this Trial Is About

Researchers are studying the prevention of catheter-related bladder discomfort CRBD, a common and painful condition after surgery, especially in patients undergoing laparoscopic radical prostatectomy. This trial evaluates whether a rectal indomethacin suppository given immediately after surgery can reduce the incidence and severity of CRBD, as well as other outcomes like pain and patient satisfaction. The trial is a randomized controlled study sponsored by Zhejiang University. Participants are randomly assigned to one of two groups one group receives a 50 mg indomethacin suppository rectally at the end of surgery, while the other group receives no treatment. Standard anesthesia protocols are followed for all patients, and certain medications that might interfere with the study are avoided. The trial measures CRBD and pain at multiple time points shortly after surgery. During the study, patients will be assessed for CRBD severity, pain levels, analgesic use, other side effects, and satisfaction at 0, 1, 2, and 6 hours after surgery. The primary focus is on moderate to severe CRBD within the first hour after surgery. The entire participation period covers these early postoperative hours, with careful monitoring by the research team to record outcomes and any adverse reactions.

Effects of Rectal Indomethacin Suppository on Postoperative CRBD in Patients Undergoing LRP