Actively Recruiting
Effects of Tuberculosis Infection on Development and Function of the Placenta
Led by Lund University · Updated on 2025-03-17
500
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
Sponsors
L
Lund University
Lead Sponsor
A
Addis Ababa University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on the placenta. The main questions it aims to answer are: * Does TB infection affect the structure of the placenta? * Does TB infection affect the function of the placenta? Pregnant women attending delivery clinics in Addis Abeba, Ethiopia, will be enrolled and classified for TB infection using a blood-based test. We will compare the following outcomes between women with TB infection and women without TB infection: * Pathological lesions of the placenta * Gene and protein expression patterns linked to pregnancy-related disorders * Infant outcome at birth and at 6 weeks after birth
CONDITIONS
Official Title
Effects of Tuberculosis Infection on Development and Function of the Placenta
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women admitted for delivery to study sites
- Written informed consent
- Age 18 years or greater
You will not qualify if you...
- Chronic comorbidities (other than TB, HIV or pregnancy-related disorder)
- Twin pregnancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Gandhi Memorial Hospital
Addis Ababa, Ethiopia
Actively Recruiting
Research Team
P
Per Bjorkman, MD, PhD
CONTACT
S
Selam Ghebrechristos, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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