Actively Recruiting
Effects of Ventilator Hyperinflation Versus Vibrocompression on Lung Compliance in Mechanically Ventilated Patients
Led by Cairo University · Updated on 2025-02-07
81
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to compare the effects of two chest physical therapy techniques—ventilator hyperinflation and vibrocompression—on lung compliance in patients who require mechanical ventilation. Mechanical ventilation helps with breathing but can cause problems such as mucus buildup, airway blockage, and lung stiffness, which increase the risk of lung infections and breathing difficulties. The study focuses on how these therapies impact lung function and sputum production in this patient group. Participants will be divided into three groups. One group will receive ventilator hyperinflation plus a traditional chest physical therapy program that includes percussion, postural drainage, and suction. Another group will receive vibrocompression combined with the traditional program. The third group will receive only the traditional chest physical therapy. Each treatment is given once daily over four consecutive days, with ventilator hyperinflation involving controlled increases in breath volume and pressure and vibrocompression involving chest vibrations during exhalation. Patients will be monitored before and after treatments on Days 1 and 4, measuring lung static compliance, airway resistance, sputum volume, and peak inspiratory and expiratory flows. Oxygen saturation will also be assessed as a secondary measure. The study includes detailed evaluations of lung function and secretion clearance to understand how each therapy affects respiratory mechanics and airway clearance. Participation lasts through the four treatment sessions and assessments.
CONDITIONS
Brief Title
Effects of Ventilator Hyperinflation Versus Vibrocompression in Mechanically Ventilated Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Mechanically ventilated patients for more than 48 hours and up to 7 days
- Age between 35 and 55 years old
- Medically stable with mean arterial pressure between 60 and 110 mmHg
- Systolic blood pressure greater than 80 mmHg
- Diastolic blood pressure greater than 60 mmHg
- Fraction of inspired oxygen less than 60%
- Positive end expiratory pressure (PEEP) less than 10 cmH2O
You will not qualify if you...
- Unstable hemodynamics
- Fraction of inspired oxygen (FiO2) equal to or greater than 60%
- PEEP equal to or greater than 10 cmH2O
- Undrained pneumothorax, hemothorax, or subcutaneous emphysema
- Pulmonary conditions such as acute respiratory distress syndrome, COPD exacerbation, or acute pulmonary edema
- Unstable neurological problems including raised intracranial pressure
- Lung cancer
- Recent or unhealed rib fracture
- Any disease that obstructs study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 4 days
Participants receive one of three treatments: ventilator hyperinflation plus a traditional chest physical therapy program, vibrocompression plus the traditional chest physical therapy program, or the traditional chest physical therapy program alone. Treatments occur once daily for 4 successive sessions.
4 daily treatment sessions
Trial Site Locations
Total: 1 location
1
Kasr AL Ainy
Cairo, Egypt
Actively Recruiting
Research Team
N
Nadia H Mohamed, MSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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