Actively Recruiting
Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet Rich Plasma to Treat Idiopathic Glossopharyngeal Neuralgia
Led by Beijing Tiantan Hospital · Updated on 2025-07-03
121
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
Sponsors
B
Beijing Tiantan Hospital
Lead Sponsor
C
China-Japan Friendship Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness and safety of combining Pulsed Radiofrequency (PRF) with Platelet Rich Plasma (PRP) to treat idiopathic Glossopharyngeal Neuralgia (GPN), a type of nerve pain. This observational study aims to compare treatment outcomes between patients receiving only PRF and those receiving PRF combined with PRP, focusing on pain relief and safety. During the study, participants receive motor stimulation at 2 Hz and 1.0V to confirm no muscle contraction before undergoing PRF treatment lasting 360 seconds at specific settings (45 V, 42°C, 2 Hz pulse rate). One group receives only PRF, while the other group also receives a slow injection of 2 ml of leukocyte-poor PRP mixture after PRF. Additional pain relief medication is available as needed. If pain relief is unsatisfactory after one month, other treatments are offered. Participants will be assessed using the Numeric Rating Scale (NRS) to measure pain at multiple time points: 1 day, 3 days, 1 week, 2 weeks, 1 month, 3 months, 6 months, and 1 year after treatment. The Barrow Neurological Institute pain scale (BNI) is also used at these times to evaluate pain. The study includes follow-up for at least one month and monitors safety through medical records and clinical evaluations throughout the study period.
CONDITIONS
Brief Title
Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet Rich Plasma to Treat Idiopathic Glossopharyngeal Neuralgia (GPN)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Diagnosed with idiopathic Glossopharyngeal Neuralgia according to the third International Classification of Headache Disorders
- Patients who failed pharmacotherapy or have intolerable medication side effects
- Undergoing Pulsed Radiofrequency treatment for Glossopharyngeal Neuralgia
- At least 1 month of follow-up recordings available
You will not qualify if you...
- Patients with bilateral Glossopharyngeal Neuralgia
- Abnormal blood tests, liver or kidney function, blood glucose, coagulation, electrocardiography, or chest X-ray
- Infection at the treatment puncture site
- History of mental illness
- History of narcotic drug abuse
- Use of anticoagulant or antiplatelet therapy prior to study
- Presence of an implantable pulse generator
- Current pregnancy or breastfeeding
- Incomplete medical records or missing baseline or follow-up data
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single treatment visit with follow-up for 1 year
Participants receive Pulsed Radiofrequency treatment. Depending on the group, some participants also receive an injection of platelet-rich plasma after the radiofrequency treatment. Additional analgesics may be given during and after the procedure for comfort.
1 treatment visit; follow-up visits at 1 day, 3 days, 1 week, 2 weeks, 1 month, 3 months, 6 months, and 1 year after treatment
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070
Actively Recruiting
Research Team
F
Fang Luo, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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