Trial of Total Diet Replacement With eHealth or Face-to-Face Support for Weight Loss and Type 2 Diabetes Remission in Overweight Adults

What this Trial Is About

Researchers are evaluating overweight adults with type 2 diabetes to study the effects of a total diet replacement aiming for weight loss and diabetes remission. The trial compares two follow-up methods eHealth-based remote support and traditional face-to-face visits. A healthy control group with normal glucose tolerance is also examined once for comparison but does not receive any intervention. The study aims to assess changes in blood sugar control and weight over time. Participants replace their usual diet with a low-calorie total diet replacement 850 kcalday for three months targeting a 15 kg weight loss and diabetes remission. After this period, food is gradually reintroduced with individualized calorie plans to prevent weight regain. Those not reaching weight loss goals may continue the diet replacement for up to two more months. Weight maintenance support includes a cognitive behavioral therapy program delivered either via an eHealth app with video calls or in-person visits, depending on group assignment. The study lasts for two years. Throughout the study, participants regularly record body weight, blood glucose, and blood pressure. HbA1c levels are measured multiple times, either at home or during visits. Various health and lifestyle factors are monitored, including medication use, blood lipids, liver enzymes, quality of life, and physical activity. After study completion, long-term outcomes will be tracked through national diabetes registries for up to 20 years. The healthy control group is examined once after one year for comparison.

The eHealth Diabetes Remission Trial