Endothelial Glycocalyx Damage in Major Spine Surgery Measured by Circulating Syndecan-1 Levels A Prospective Observational Pilot Study GlycOrtho

What this Trial Is About

Researchers are investigating endothelial damage during major spine surgery by measuring the rise of circulating Syndecan-1, a marker of glycocalyx shedding. The study focuses on different surgical groups, including adolescent idiopathic scoliosis, adult degenerative spine disease, and oncologic surgery. This observational pilot study aims to better understand how major spine surgery affects the endothelium, which has been less studied compared to shock conditions like sepsis or trauma. Blood samples will be taken at various times to track changes in Syndecan-1 levels: before surgery, immediately after surgery, before and after any Fresh Frozen Plasma transfusions, and on postoperative days 1, 2, and 4. The study also explores whether Fresh Frozen Plasma transfusions influence endothelial damage, as previous research suggests a possible protective effect. The findings will help guide future clinical trials on how to reduce endothelial injury during surgery. Participants will have blood draws at scheduled times to measure Syndecan-1 changes. Researchers will analyze the amount of endothelial glycocalyx shedding and differences across patient groups and surgical types. The primary outcome is the change in Syndecan-1 levels from baseline to day 1 after surgery. Secondary outcomes include tracking Syndecan-1 levels over several postoperative days and comparing results among different patient populations. The study is expected to conclude by September 2026.

Endothelial Damage in Major Spine Surgery, Measured by Circulating Syndecan-1: an Observational Study.(GlycOrtho)