Actively Recruiting
Endothelial Damage in Major Spine Surgery, Measured by Circulating Syndecan-1: an Observational Study.(GlycOrtho)
Led by Istituto Ortopedico Rizzoli · Updated on 2024-11-13
30
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to learn about endothelial damage in major spine surgery, expressed as rise in circulating Syndecan-1. The main questions it aims to answer are: * What is the extent of endothelial glycocalyx shedding in major spine surgery? * Are there differences in different type of surgical populations? (adolescent idiopathic scoliosis, adult degenerative spine disease, oncologic surgery) To do so, blood samples will be drawn from participants at the following timepoints: * basal * after surgery * if transfusion of Fresh Frozen Plasma: before and after transfusion * Post-Operative Day 1-2-4
CONDITIONS
Official Title
Endothelial Damage in Major Spine Surgery, Measured by Circulating Syndecan-1: an Observational Study.(GlycOrtho)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Undergoing major spine surgery with estimated blood loss greater than 25% of total blood volume
- American Society of Anesthesiology status 1, 2, or 3
- Able to understand and sign informed consent
- If under 18 years old, a parent or legal representative must be able to understand and sign informed consent
You will not qualify if you...
- Surgery scheduled outside of laboratory opening hours
- Spine surgery performed for genetic syndromes or neuromuscular scoliosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sandra Giannone
Bologna, BO, Italy, 40128
Actively Recruiting
Research Team
S
Sandra Giannone, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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