Randomized Study Comparing Endoscopic and Surgical Gastrojejunostomy for Treating Gastric Outlet Obstruction in Patients with Periampullary or Distal Gastric Cancer

What this Trial Is About

Gastric outlet obstruction GOO often occurs in cancers involving the periampullary region or distal stomach, leading to severe symptoms like nausea, vomiting, and difficulty eating. This condition affects patients nutritional status and quality of life, making effective therapy important to help them continue cancer treatment. The study compares two methods to treat GOO endoscopic and surgical gastrojejunostomy. Participants will be randomly assigned to receive either a laparoscopic surgical gastrojejunostomy, which creates an anastomosis between the stomach and jejunum, or an endoscopic ultrasound-guided gastrojejunostomy, where a stent is placed between the stomach and small intestine. Both procedures aim to relieve obstruction and improve oral intake. The study collects data before, during, and after procedures, with follow-up points up to one year. During the study, participants complete quality of life questionnaires and undergo clinical assessments including symptom scores, gut function, weight, and performance scales. Data on procedure safety, technical and clinical success, time to oral intake, hospital discharge, and tolerance of chemotherapy are collected. Follow-up visits occur frequently in the first week, then at 30 days, 3 months, 6 months, and 1 year to monitor outcomes and changes in health status.

Enteral Anastomosis for the Treatment of Gastric Outlet Obstruction: A Randomized Controlled Study Comparing Endoscopic Versus Surgical Gastrojejunostomy