Actively Recruiting
Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients
Led by Southeast University, China · Updated on 2024-08-16
60
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the patterns of airway pressure and lung behavior in critically ill patients who require mechanical ventilation. The study focuses on understanding how airway closure and alveolar collapse affect ventilation, using tools like the quasi-static pressure-volume (PV) curve and electrical impedance tomography (EIT). These methods aim to provide detailed regional and global information about lung function in this patient group. Participants will undergo a pressure-volume curve test with a low-flow insufflation of 5 liters per minute while under analgesia, sedation, and without spontaneous breathing. This test measures airway pressure starting from zero up to the plateau pressure to evaluate lung mechanics, specifically the rate of airway closure and alveolar collapse. The study is interventional and does not involve masking or blinding. During the study, researchers will monitor and measure the rate of airway closure and alveolar collapse, the phenotype of respiratory open pressure, and respiratory system compliance over a 24-hour period. Patients must be on controlled mechanical ventilation with intubation lasting less than 48 hours. The trial includes assessments related to lung function and ventilation mechanics while ensuring patient safety under sedation and analgesia.
CONDITIONS
Brief Title
Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients undergoing controlled mechanical ventilation
- Endotracheal intubation duration less than 48 hours
You will not qualify if you...
- Severe hemodynamic instability
- Severe chronic lung disease requiring long-term home oxygen therapy
- Patients without analgesic sedation
- Decline to participate in the study
- Refusal to sign informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 24 hours
Participants undergo a pressure-volume curve with a low-flow insufflation of 5 L/min while in a state of analgesia and sedation without spontaneous breathing to assess respiratory phenotype.
1 procedure during hospitalization
Trial Site Locations
Total: 1 location
1
Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University
Nanjing, Jiangsu, China, 210000
Actively Recruiting
Research Team
L
ling liu, phD
X
xueyan yuan, phD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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