Study of Airway Pressure and Lung Function Using Pressure-Volume Curve in Critically Ill Adults on Mechanical Ventilation

What this Trial Is About

Researchers are investigating the patterns of airway pressure and lung behavior in critically ill patients who require mechanical ventilation. The study focuses on understanding how airway closure and alveolar collapse affect ventilation, using tools like the quasi-static pressure-volume PV curve and electrical impedance tomography EIT. These methods aim to provide detailed regional and global information about lung function in this patient group. Participants will undergo a pressure-volume curve test with a low-flow insufflation of 5 liters per minute while under analgesia, sedation, and without spontaneous breathing. This test measures airway pressure starting from zero up to the plateau pressure to evaluate lung mechanics, specifically the rate of airway closure and alveolar collapse. The study is interventional and does not involve masking or blinding. During the study, researchers will monitor and measure the rate of airway closure and alveolar collapse, the phenotype of respiratory open pressure, and respiratory system compliance over a 24-hour period. Patients must be on controlled mechanical ventilation with intubation lasting less than 48 hours. The trial includes assessments related to lung function and ventilation mechanics while ensuring patient safety under sedation and analgesia.

Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients