Actively Recruiting
Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients
Led by Southeast University, China · Updated on 2024-08-16
60
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Monitoring airway pressure is essential for patients with mechanical ventilation. However, static airway pressure does not reflect alveolar pressure at all. Airway pressure is supposed to completely interrupt the communication between proximal airway opening and the distal alveolar and/or small airway structures. In this condition, some alveoli may still be inflated but do not communicate with proximal airways and auto-PEEP will give a biased estimated of mean alveolar pressure. To be note, distinguishing the airway closure and alveolar collapse can be challenging at times. The quasi-static PV curve is a useful bedside tool to set mechanical ventilation, which may help us to identify the airway closure and alveolar collapse. Meanwhile, the quasi-static PV curve can only reflects a global behaviour of the lung, while EIT may be a useful tool to assess the regional information on airway closure and alveolar collapse.
CONDITIONS
Official Title
Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients undergoing controlled mechanical ventilation
- Duration of endotracheal intubation less than 48 hours
You will not qualify if you...
- Severe hemodynamic instability
- Severe chronic lung disease requiring long-term home oxygen therapy
- Patients without analgesic sedation
- Decline to participate in the study
- Refusal to sign informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University
Nanjing, Jiangsu, China, 210000
Actively Recruiting
Research Team
L
ling liu, phD
CONTACT
X
xueyan yuan, phD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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