Actively Recruiting
Estimation of Biomechanical Aortic Wall Properties in Healthy and Aneurysmal Aortas Using Novel Imaging Techniques
Led by Mayo Clinic · Updated on 2025-09-11
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to assess the practicality of two new imaging techniques for measuring the biomechanical properties of the aorta in patients with abdominal aortic aneurysm (AAA) and healthy individuals. The study involves comparing groups with no surgery, open surgery, and endovascular aneurysm repair (EVAR) to understand relationships between aortic wall properties and clinical outcomes such as aneurysm growth and rupture risk. Patients who meet surgery indications including symptomatic AAA, large size, or rapid growth will undergo standard preoperative assessments modified to include ECG-gated magnetic resonance angiogram (MRA) and 2-dimensional speckle-tracking ultrasound (ECHO) of the abdominal aorta. These imaging methods will be used across the three patient groups: surveillance without surgery, open surgery, and EVAR. Patients will be followed for one year to monitor changes. Participants will receive imaging assessments including ECHO and ECG-gated MRA at baseline and during follow-up. Researchers will analyze changes in ECHO imaging as the primary outcome and changes in ECG-gated MRA as a secondary outcome. Patients with AAA will be monitored for aneurysm progression and related clinical events. The study does not use random assignment or masking, and participation will involve standard preoperative and follow-up imaging over one year.
CONDITIONS
Brief Title
Estimation of Biomechanical Aortic Wall Properties in Healthy and Aneurysmal Aortas Using Novel Imaging Techniques
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years of age who can provide informed consent
- Patients with symptomatic or asymptomatic abdominal aortic aneurysm defined as aortic diameter at least 1.5 times normal
- Patients with non-aneurysmal aortas requiring aortic contrast imaging or echocardiography for preoperative planning or other reasons
You will not qualify if you...
- Patients allergic to intravenous contrast or with severe kidney dysfunction
- Patients not requiring contrast imaging or echocardiogram as part of their care plan
- Terminally ill patients or those with life expectancy 6 months or less
- Patients unable to tolerate magnetic resonance imaging
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Pre-operative period as per routine care
Participants undergo imaging studies, including ECHO and ECG-gated MRA, to assess aortic wall properties before any intervention.
1 to 2 visits depending on group assignment
Duration - Up to 1 year
Participants with no surgery are monitored using ECHO and ECG-gated MRA imaging to observe aortic aneurysm status.
Periodic imaging visits during the year
Duration - Duration of surgical intervention and immediate care
Participants undergo open surgery or EVAR to repair the aortic aneurysm with associated imaging assessments.
1 surgical visit plus standard post-operative imaging visits
Duration - Up to 1 year after intervention or surveillance
Participants are followed for up to 1 year with imaging assessments to monitor aortic wall properties and clinical outcomes after surgery or surveillance.
Multiple imaging visits during follow-up
Trial Site Locations
Total: 1 location
1
Mayo Clinic Florida
Jacksonville, Florida, United States, 32224
Actively Recruiting
Research Team
H
Houssam Farres, MD
M
Mauricia Buchanan, RN
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
3
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here