Estimation of Diaphragm Electrical Activity and Intercostal Thickening Fraction During Mechanical Ventilation in Difficult Weaning Patients: PSV Versus NAVA

What this Trial Is About

Respiratory muscle dysfunction, especially in the diaphragm and external intercostal muscles, is a major cause of difficulty when trying to stop mechanical ventilation (MV) in critically ill patients. Researchers are evaluating the use of different ventilation methods to reduce weaning failure. This study focuses on comparing two ventilation modes, Pressure Support Ventilation (PSV) and Neurally Adjust Ventilatory Assist (NAVA), in patients who have trouble weaning from MV in the intensive care unit (ICU). NAVA also allows measurement of diaphragm electrical activity, which may help assess breathing effort and predict weaning outcomes. The study observes patients with difficult weaning from MV, comparing intercostal thickening fraction (TFic) values during PSV and NAVA ventilation modes. These measurements help evaluate inspiratory muscle function and breathing effort. The study aims to assess respiratory muscle activity and breathing synchrony during these ventilation methods. Data is collected from patients admitted in ICU who have been on mechanical ventilation for at least 24 hours and have failed at least one weaning attempt. Participants will be monitored from enrollment until extubation, up to seven days. Researchers will assess intercostal thickening fraction, diaphragm electrical activity, and other breathing effort parameters. The study involves non-invasive imaging and measurement techniques to evaluate respiratory muscle function without changing patients' standard care. The goal is to better understand muscle function during different ventilation methods to improve management of patients struggling to wean from mechanical ventilation.

Estimation of the Diaphragm Electrical Activity and Intercostal Thickening Fraction During Different Pattern of Mechanical Ventilation: PSV Versus NAVA