Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study.
R A Mulnard, C W Cotman, C Kawas...
https://pubmed.ncbi.nlm.nih.gov/10697060Completed
Phase 3
Age: 60Years +
FEMALE
ID00000177
Estrogen Hormone Protocol
Led by National Institute on Aging (NIA) · Updated on 2009-12-11
120
Participants Needed
25
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Estrogen is a hormone that is dominant in the female reproductive system. In women, most estrogen is produced by the ovaries. Men produce estrogen by converting testosterone into estrogen. Because this hormone also has many beneficial effects on brain cells, it currently is being studied as a treatment for Alzheimer's disease. The enzyme that forms the neurotransmitter acetylcholine is promoted in the presence of estrogen. Several very small clinical studies have demonstrated improvement in cognitive function and mood measures in women with Alzheimer's disease who take estrogen.
CONDITIONS
Brief Title
Estrogen Hormone Protocol
Who Can Participate
Age: 60Years +
FEMALE
Eligibility Criteria
You may qualify if you...
- Women with a diagnosis of Alzheimer's disease who currently are not taking estrogen replacement therapy, who have had a hysterectomy, and who are in stable general health.
You will not qualify if you...
- Patients with an uncontrolled health problem, such as untreated high blood pressure or thyroid disease.
Trial Site Locations
Total: 25 locations
1
University of Alabama, Birmingham
Birmingham, Alabama, United States, 35294-0017
Status Unknown
2
University of California, San Diego
San Diego, California, United States, 92093
Status Unknown
3
Mayo Clinic Jacksonville
Jacksonville, Florida, United States, 32225
Status Unknown
4
University of South Florida
Tampa, Florida, United States
Status Unknown
5
Emory University
Atlanta, Georgia, United States, 30329
Status Unknown
6
Rush Presbyterian St. Luke's Medical Center
Chicago, Illinois, United States, 60612
Status Unknown
7
Southern Illinois University
Springfield, Illinois, United States, 62702
Status Unknown
8
Indiana University Medical Center
Indianapolis, Indiana, United States, 46202-5266
Status Unknown
9
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Status Unknown
10
University of Kentucky
Lexington, Kentucky, United States, 40536-0230
Status Unknown
11
Johns Hopkins University
Baltimore, Maryland, United States, 21224
Status Unknown
12
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Status Unknown
13
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Status Unknown
14
Mayo Clinic
Rochester, Minnesota, United States, 55901-0144
Status Unknown
15
Washington University
St Louis, Missouri, United States, 63110
Status Unknown
16
New York University Medical Center
New York, New York, United States, 10016
Status Unknown
17
Mount Sinai School of Medicine
New York, New York, United States, 10029
Status Unknown
18
Columbia Presbyterian Medical Center
New York, New York, United States, 11032
Status Unknown
19
Burke Medical Research Institute
White Plains, New York, United States, 10605
Status Unknown
20
University Hospitals of Cleveland
Cleveland, Ohio, United States, 44120
Status Unknown
21
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Status Unknown
22
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Status Unknown
23
University of Texas
Dallas, Texas, United States, 75235
Status Unknown
24
Baylor College of Medicine
Houston, Texas, United States, 77030
Status Unknown
25
University of Washington
Seattle, Washington, United States, 98195
Status Unknown
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How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
N/A
Primary Purpose
TREATMENT
Number of Arms
0
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