Actively Recruiting
Evaluating Atherosclerotic Disease Progression in Patients With Diabetes Mellitus
Led by Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Updated on 2025-11-20
1000
Participants Needed
2
Research Sites
590 weeks
Total Duration
On this page
Sponsors
A
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Lead Sponsor
H
Horizon Innovative Health Initiative
Collaborating Sponsor
AI-Summary
What this Trial Is About
People with type 2 diabetes have a much higher risk of heart disease. One common problem is when the blood vessels that supply the heart become narrowed or blocked by fatty deposits, called plaque. This makes it harder for blood to reach the heart and can lead to serious problems such as chest pain, heart attacks, or even death. This study will follow people with type 2 diabetes who have already had a special heart scan called a coronary CT angiography. This scan takes detailed pictures of the heart's blood vessels. The goal is to understand how heart disease changes over time in people with type 2 diabetes, by looking at repeat scans and other health information. By learning more about how plaque builds up or gets worse, researchers hope to find better ways to identify which patients are most at risk for future heart problems.
CONDITIONS
Official Title
Evaluating Atherosclerotic Disease Progression in Patients With Diabetes Mellitus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Previous completion of CCTA scan for coronary artery disease assessment
- Diagnosed with type 2 diabetes and currently receiving glucose lowering treatment
- Sufficient image quality of the CCTA scan (at least 2 out of 3 vessels must be of sufficient quality for assessment)
You will not qualify if you...
- Inability to provide written informed consent
- Presence of an unstable medical condition
- Severe kidney dysfunction preventing CCTA (eGFR ≤ 30 mL/min/1.73m²) or known allergy or contraindication to CT contrast agents
- Any treatment or medical condition that may interfere with the study conduct or results as judged by the investigator
- Inability or unwillingness to comply with study protocol or deemed unfit by the investigator
- Baseline CCTA scan performed less than 2 years or more than 5 years before study inclusion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Amsterdam University Medical Centers
Amsterdam, Netherlands
Not Yet Recruiting
2
Cardiology Centers of the Netherlands
Amsterdam, Netherlands
Actively Recruiting
Research Team
W
Willem R van de Vijver, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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