Actively Recruiting
Multicenter Study on the Evaluation of Adherence, Persistence and Efficacy of Treatment With PCSK9 Inhibitors in Italy
Led by Federico II University · Updated on 2026-01-22
5000
Participants Needed
27
Research Sites
426 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the adherence, persistence, and effectiveness of PCSK9 inhibitors in treating hypercholesterolemia among a real-life Italian population. This observational study focuses on patients receiving these medications to better understand treatment patterns and outcomes outside of controlled clinical trials. Participants in this study are patients with hyperlipidemia who are currently treated with PCSK9 inhibitors, specifically Repatha (evolocumab) or Praluent (alirocumab), administered by injection. The study observes these patients without altering their treatment, collecting data over time to assess how well patients stick to their treatment plans and how effective the medications are. During the study, researchers will gather information every six months about treatment adherence, persistence, and efficacy. They will also monitor safety and analyze results within different patient subgroups. Participation includes regular assessments of medication use and health outcomes, with the study continuing until March 31, 2030.
CONDITIONS
Brief Title
Evaluation of Adherence, Persistence and Efficacy of Treatment With PCSK9 Inhibitors in Italy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients under PCSK9 inhibitor treatment.
You will not qualify if you...
- Age under 18 years or over 80 years.
- Patients who refuse to participate and to sign informed consent.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 8 years
Participants who are under treatment with PCSK9 inhibitors are observed to evaluate adherence, persistence, and efficacy.
Visits every 6 months
Trial Site Locations
Total: 27 locations
1
Ospedali dell'Ovest Vicentino
Arzignano, Italy, 36071
Actively Recruiting
2
University of Bari Aldo Moro
Bari, Italy, 70121
Actively Recruiting
3
University of Campania Luigi Vanvitelli
Caserta, Italy, 81100
Actively Recruiting
4
University Magna Graecia of Catanzaro
Catanzaro, Italy, 88100
Actively Recruiting
5
Presidio Ospedaliero Maria SS Addolorata
Eboli, Italy, 84025
Actively Recruiting
6
Policlinico Riuniti Foggia
Foggia, Italy, 71122
Actively Recruiting
7
Università degli Studi di Genova
Genova, Italy, 16126
Actively Recruiting
8
Ospedale di Lecce
Lecce, Italy, 73100
Actively Recruiting
9
Università degli Studi di Messina
Messina, Italy, 98122
Actively Recruiting
10
Policlinico di Milano Ospedale Maggiore - Fondazione IRCCS Ca' Granda
Milan, Italy, 20122
Actively Recruiting
11
ASST Grande Ospedale Metropolitano Niguarda
Milan, Italy, 20162
Actively Recruiting
12
AORN dei Colli - Ospedale monaldi
Naples, Italy, 80131
Actively Recruiting
13
Federico II University of Naples, Department of Advanced Biomedical Sciences
Naples, Italy, 80131
Actively Recruiting
14
Federico II University of Naples, Department of Translational Medical Sciences
Naples, Italy, 80131
Actively Recruiting
15
University of Naples Federico II, Department of Clinical Medicine and Surgery
Naples, Italy, 80131
Actively Recruiting
16
Azienda Ospedaliero-Universitaria "Maggiore della Carità"
Novara, Italy, 28100
Actively Recruiting
17
Azienda Ospedaliero-Univeristaria di Parma
Parma, Italy, 43126
Actively Recruiting
18
Presidio Ospedaliero Pescara
Pescara, Italy, 65124
Actively Recruiting
19
Ospedale di Rivoli
Rivoli, Italy, 10098
Actively Recruiting
20
Policlinico Tor Vergata
Roma, Italy, 00133
Actively Recruiting
21
Azienda Ospedaliera San Camillo-Forlanini
Roma, Italy, 00152
Actively Recruiting
22
Policlinico Casilino
Roma, Italy, 00169
Actively Recruiting
23
Sapienza University of Rome
Roma, Italy, 00185
Withdrawn
24
Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d'Aragona
Salerno, Italy, 84131
Actively Recruiting
25
Ospedale SS Annunziata A.O.U.
Sassari, Italy, 07100
Actively Recruiting
26
University of Siena
Siena, Italy, 53100
Actively Recruiting
27
Azienda Ospedaliera Ordine Mauriziano Torino
Torino, Italy, 10128
Actively Recruiting
Research Team
P
Pasquale Perrone Filardi, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here