Current methods for stress marker detection in saliva.
Ginevra Giacomello, Andreas Scholten, Maria Kristina Parr
https://pubmed.ncbi.nlm.nih.gov/32957066Actively Recruiting
Age: 18Years - 60Years
All Genders
Healthy Volunteers
ID07320040
Evaluation of Emotion-related Salivary Molecular Biomarkers Following Olfactory Stimuli
Led by Sys2Diag · Updated on 2026-01-29
240
Participants Needed
1
Research Sites
221 weeks
Total Duration
On this page
Sponsors
S
Sys2Diag
Lead Sponsor
C
Centre National de la Recherche Scientifique, France
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how emotional states can be identified through physiological responses controlled by enzymes and hormones linked to the autonomic nervous system. This observational study focuses on measuring specific molecular biomarkers in saliva to better understand an individual's emotional state, especially in reaction to smells. Participants will be exposed to both fragrance and placebo in different sequences to observe changes in salivary biomarkers such as cortisol, alpha-amylase, DHEA, and oxytocin. These biomarkers will be measured using non-invasive saliva tests with enzymatic and ELISA methods to identify emotional responses to olfactory stimuli. During the study, saliva samples will be collected and analyzed to evaluate variations and patterns of these biomarkers over time. Researchers will also correlate biomarker levels with emotional ratings, aiming to establish a molecular signature of emotions. The study involves adults aged 18 to 60 and includes safety and compliance monitoring throughout the research period, which spans several years for different outcome measures.
CONDITIONS
Brief Title
Evaluation of Emotion-related Salivary Molecular Biomarkers
Who Can Participate
Age: 18Years - 60Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Subject willing to follow study procedures
- Subject able to understand the purpose, nature and methodology of the study
- Subject has signed informed consent form
- Subjects between 18 and 60 years of age
You will not qualify if you...
- Subjects deprived of liberty, protected adults, vulnerable persons or minors
- Subjects with a proven or suspected chronic infectious disease that could entail a risk of contamination during sample handling
- Rejection to sign the consent form
- Pregnant or breastfeeding women
- Subjects presenting anosmia during the last 15 days
- Subjects presenting symptoms and signs of active oral inflammation, advanced periodontitis or severe gingivitis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Up to 3 years
Participants provide saliva samples for measurement of molecular biomarkers before and after exposure to fragrance and placebo olfactory stimuli.
Multiple visits for saliva sample collection over several years
Long-term Monitoring
Duration - Up to 3 years
Participants are observed to evaluate variations and correlations of biomarker signatures and emotional responses over time.
Periodic visits for assessment and sample collection
Trial Site Locations
Total: 1 location
1
SYS2DIAG - UMR9005 CNRS/ALCEN, Montpellier, 34184
Montpellier, France
Actively Recruiting
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Research Team
W
Wendpouiré A OUEDRAOGO, Msc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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