Prolonged Grief Disorder: Course, Diagnosis, Assessment, and Treatment.
Kristin L Szuhany, Matteo Malgaroli, Carly D Miron...
https://pubmed.ncbi.nlm.nih.gov/34690579/Actively Recruiting
Led by University of South Florida · Updated on 2026-01-21
140
Participants Needed
1
Research Sites
12 weeks
Total Duration
Researchers are investigating how self-affirmation may affect cardiovascular responses during grief. The study focuses on young adults who have experienced a recent loss, exploring how self-affirmation tasks might influence heart rate, blood pressure, and other cardiovascular measures during and after recalling grief. It also examines the relationship between grief severity and psychological stress including depression, anxiety, and sleep quality. Participants will be randomly assigned to either a self-affirmation task, where they rank personal values and write about their top choice, or a control task involving ranking jellybean flavors. Both tasks last about 10 minutes and are followed by a grief recall interview designed to elicit grief-related stress. Cardiovascular data will be collected throughout, including ECG, impedance cardiography, and blood pressure measurements. The study includes a rest period before tasks and a recovery period afterward. During the visit, participants complete questionnaires on health, grief, depression, anxiety, and stress. Height and weight are measured, and cardiovascular monitoring devices are attached. The study lasts through the self-affirmationcontrol task, grief recall interview, and a quiet recovery phase. Researchers will analyze cardiovascular reactivity and recovery to grief recall, as well as psychological stress measures. The total involvement includes consent, questionnaires, physiological monitoring, interviews, and final assessments.
CONDITIONS
Cardiovascular Effects of Grieving
K
Kaiyuan Luo, BS, BA
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University of South Florida
Lead Sponsor
Arizona State University
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Value-affirmation intervention | Control group (no intervention) |
|---|---|---|
| What it is | Participants undertake a value-affirmation exercise, ranking important personal values and writing about their top-ranked value to promote positive self-worth and reduce grief-related distress. | Participants do not perform any behavioral intervention or value-affirmation exercise and act as controls for study outcomes. |
| Role in trial | This arm tests whether self-affirmation reduces cardiovascular reactivity and psychological stress following grief recall tasks. | The control arm measures cardiovascular and psychological response to grief recall in the absence of the intervention. |
| Primary use | Studied as a brief behavioral strategy to reduce cardiovascular reactivity and psychological stress for grieving adults. | Serves as observation-only control to quantify the natural response to grief recall among eligible adults. |
| How it is given/performed | Participants rank 11 personal values, identify their most important value, and spend 10 minutes writing about how that value makes them feel good about themselves. | Participants do not perform any ranking or writing task. No intervention is administered. |
| Evidence status | Self-affirmation interventions have published evidence for reducing stress and improving cardiovascular responses, though evidence is limited for grief-specific outcomes. | Observational evidence links grief with increased cardiovascular morbidity and mortality; natural response is compared against intervention effects. |
| Important limitations | Effectiveness of value-affirmation in grief-related cardiovascular outcomes is not yet established, and most published self-affirmation studies did not target bereaved adults. | No active behavioral support is offered, so natural distress and cardiovascular risk may remain unaddressed during bereavement. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Approximately 1 day
Participants complete questionnaires and have their height and weight measured. Cardiovascular measurement equipment is then attached before resting quietly while physiological data is collected.
1 visit (in-person)
Duration - 10 minutes
Participants are randomly assigned to either a self-affirming task or a neutral control task. During this 10-minute task, physiological data is collected to assess cardiovascular responses.
1 visit (in-person)
Duration - 10 minutes
Participants engage in a guided 10-minute grief recall interview designed to elicit grief and related cardiovascular responses while physiological data is collected.
1 visit (in-person)
Duration - 10 minutes
Participants sit quietly for a 10-minute recovery period while physiological measurements continue to be collected.
1 visit (in-person)
Duration - Approximately 30 minutes
Participants complete additional questionnaires assessing self-worth, grief responses, and psychological states before the study concludes.
1 visit (in-person)
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/19652695/University of South Florida
Lead Sponsor
Arizona State University
Collaborating Sponsor