Actively Recruiting
Evaluation of the Safety of Terahertz Scanning System on Corneas: Phase I Trial
Led by Singapore Eye Research Institute · Updated on 2025-05-16
5
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the safety of using a Terahertz (THz) scanning system on people with corneal diseases. This observational study focuses on participants who have eyes that are functionally blind but still have healthy corneas. The study aims to determine if the THz scanning system is safe to use on the human cornea by monitoring eye health over time. Corneal disease is a major cause of irreversible blindness worldwide, and monitoring corneal water content is important for detecting conditions leading to vision loss.
CONDITIONS
Brief Title
Evaluation of the Safety of Terahertz Scanning System on Corneas
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be at least 21 years of age
- Any gender
- Any race
- Willing and able to follow study instructions and schedule
- Have at least one eye that is functionally blind but has a healthy cornea
- Able to keep face sufficiently stable for scans
- Best spectacle corrected visual acuity of hand motion or worse in the study eye
You will not qualify if you...
- Pregnant or breastfeeding women
- Eyes with previous major corneal surgery such as transplantation, refractive surgery, or cross-linking
- Eyes with previous infectious keratitis
- Eyes with long-term use of glaucoma eye drops
- Eyes with moderate or severe meibomian gland dysfunction
- Eyes with active inflammation, infection, or chronic ocular surface inflammation
- Systemic diseases affecting the eye surface, including autoimmune diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single session
Participants undergo a non-invasive and non-contact Terahertz (THz) scanning using the THz Imaging system to assess corneal hydration status and safety.
1 visit (in-person)
Duration - 1 month
Participants are monitored for safety and changes in eye health following the THz scan, including assessments of visual acuity and corneal health.
Follow-up visits within 1 month
Trial Site Locations
Total: 1 location
1
Singapore National Eye Centre
Singapore, Singapore, Singapore, S169856
Actively Recruiting
Research Team
Y
Yu-Chi Liu
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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