Study to Validate Terahertz Scanning System for Corneal Scars and Edema Using Non-Invasive Imaging to Monitor Corneal Disease Progression

What this Trial Is About

Researchers are evaluating the use of a Terahertz THz scanning system as a new imaging method for people with corneal edema or corneal scars. These eye conditions can cause vision problems and may lead to corneal transplantation when advanced. The study aims to see if this THz scanning system can accurately measure the hydration level and density of the cornea, which current clinical tools cannot do objectively. This could help in early detection and better monitoring of disease progression to guide treatment decisions. The study involves patients with corneal endothelial dysfunction causing edema or those with corneal scars without edema. Participants will undergo a quick, non-invasive THz scan that takes about one second, developed by the Institute of Materials Research and Engineering in Singapore. This will be followed by standard clinical examinations to compare results. The THz systems performance will be assessed by correlating its measurements with traditional clinical methods. During the study, participants will have their eyes scanned with the THz device and undergo various clinical assessments such as corneal thickness, density, and appearance evaluations. Researchers will measure several baseline outcomes including the National Eye Institute NEI Score and keratocyte activation extent. This observational study is led by the Singapore Eye Research Institute and will run until August 2026. Participants will be monitored at scheduled visits to collect detailed data on their eye condition.

Validation of the Use of Terahertz Scanning System on Corneal Scars and Corneal Edema