Exercise Cardiac MRI Study for Patients with Paradoxical or Conventional Low-Flow Low-Gradient Severe Aortic Stenosis

What this Trial Is About

Researchers are studying patients with paradoxical or conventional severe low-flow low-gradient aortic stenosis, a heart valve condition, to better understand their health outcomes. The study focuses on using exercise-stress cardiac magnetic resonance imaging CMR along with standard guideline-recommended assessments before patients undergo transcatheter aortic valve replacement TAVR. This observational study aims to observe how these diagnostic tools relate to serious heart-related events over time. Participants will undergo a physiological exercise-stress CMR scan lasting about 40 minutes, in addition to other standard heart evaluations as recommended by medical guidelines. The study groups include patients with paradoxical low-flow low-gradient aortic stenosis and those with conventional low-flow low-gradient aortic stenosis. The exercise-stress CMR is performed while the participant is in a supine position. During the study, researchers will monitor participants for up to 12 months to track the composite outcome of cardiovascular death or hospitalization due to heart failure. Participants will be assessed through imaging and clinical evaluations to gather data on their heart condition and response to exercise stress. The study does not involve treatment but focuses on observing participant health and events after their diagnostic assessments.

Exercise CMR in (p)LF-LG AS