Study of Brain Blood Flow, Metabolism, and Thinking Abilities in Adults with Unruptured Brain Arteriovenous Malformations Before and After Surgery

What this Trial Is About

This research aims to better understand how unruptured brain arteriovenous malformations AVMs affect blood flow and metabolism in different brain areas before and after surgical treatment in adults. These AVMs are serious conditions that can cause brain bleeding or neurological problems, but it is unclear how surgery impacts brain function and cognitive abilities. The study seeks to improve knowledge about AVMs and their treatment effects on brain function and neurocognitive health. Participants will undergo specialized imaging using 18F-FDG PET scans before surgery and again six months afterward to observe changes in brain metabolism and blood flow. They will also have detailed neuropsychological assessments through standard tests to evaluate cognitive functions and psychological impact before surgery and at three and six months post-surgery. The PET scan involves an injection of a radiotracer and takes about 1.5 hours, while cognitive testing lasts 2 to 3 hours per visit. Throughout the study, participants will be monitored for changes in brain metabolism, cognitive abilities, and symptom impact such as headaches. Researchers will measure specific brain function markers including glucose metabolism rates and attention, memory, and executive functions. The total follow-up includes assessments at baseline, three months, and six months after surgery, allowing for comprehensive evaluation of surgical effects on brain health and cognition.

Exploratory Study of Cerebral Perfusion and Metabolic Alterations and Neurocognitive Disorders in Patients With Unruptured Arteriovenous Malformations Before and After Surgical Treatment