Genome-wide association study of neuropathic pain.
Mari Spildrejorde, Øystein Dunker, Sara Maria Allen...
https://pubmed.ncbi.nlm.nih.gov/41359007Actively Recruiting
Age: 18Years - 70Years
All Genders
ID03862365
Exploring the Genetics of Neuropathic Pain
Led by Oslo University Hospital · Updated on 2023-11-07
5000
Participants Needed
5
Research Sites
52 weeks
Total Duration
On this page
Sponsors
O
Oslo University Hospital
Lead Sponsor
H
Haukeland University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Neuropathic pain, caused by damage or disease of the somatosensory nervous system, affects about 7-8% of people worldwide and remains a significant health challenge. This research aims to find new genetic variants linked to the development of neuropathic pain by studying patients with and without this condition. The study builds on previous genetic findings from rare neuropathic disorders to better understand why only some people with nerve damage develop neuropathic pain. Participants will undergo clinical and diagnostic evaluations for different types of neuropathies, including polyneuropathy, diabetic polyneuropathy, and carpal tunnel syndrome, with or without pain. Genetic testing will be performed to compare patients across these groups. The study uses existing population data and a new registry and biobank for patients with neuropathy, collaborating internationally to include a large number of participants. During the study, participants will complete questionnaires and clinical assessments related to their neuropathic pain status. Researchers will analyze genetic variants and classify pain presence and severity using grading systems. Results will be shared regularly with hospitals, patients, and the public through various channels. The study is expected to enhance understanding of neuropathic pain mechanisms, potentially guiding future treatments.
CONDITIONS
Brief Title
Exploring the Genetics of Neuropathic Pain
Who Can Participate
Age: 18Years - 70Years
All Genders
Eligibility Criteria
You may qualify if you...
- The patient is between 18 and 70 years old.
- The patient has consented to participate.
- The patient is referred for evaluation of possible distal symmetric polyneuropathy.
- The patient has completed the required questionnaires.
You will not qualify if you...
- The patient is too sick to participate (e.g., bedridden or has a fever).
- The patient cannot give consent (e.g., due to dementia, speech problems, or psychiatric disorders).
- The patient has inflammatory acute polyneuropathy.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Baseline
Participants undergo clinical and diagnostic testing to determine the presence and subtype of neuropathic pain or polyneuropathy.
1 visit (in-person)
Long-term Monitoring
Duration - Ongoing during study period
Participants are observed over time to identify genetic variants associated with neuropathic pain and to analyze pain phenotypes.
Visits as needed for assessments and sample collection
Trial Site Locations
Total: 5 locations
1
Haukeland University Hospital
Bergen, Norway, 5021
Actively Recruiting
2
Oslo University Hospital
Oslo, Norway, 0450
Actively Recruiting
3
Helse Stavanger HF
Stavanger, Norway, 4011
Actively Recruiting
4
University Hospital of North Norway
Tromsø, Norway, 9019
Actively Recruiting
5
St. Olavs Hospital
Trondheim, Norway, 7030
Actively Recruiting
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Research Team
K
Kristian B. Nilsen, M.D
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
6
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