Study of Follicular Volume and Oocyte Maturity in Women with Low Ovarian Reserve During Ovarian Stimulation for IVF or Egg Freezing

What this Trial Is About

Researchers are studying women with severely diminished ovarian reserve and monofollicular growth who face higher risks of premature ovulation and poor quality eggs. The study aims to evaluate the relationship between follicular volume at the time of final oocyte maturation and oocyte maturity to improve timing of trigger administration and possibly increase chances of obtaining healthy embryos. Participants will undergo ovarian stimulation using an antagonist protocol with Pergoveris at a starting dose of 450 IU. The antagonist begins on day 5 of stimulation, and trigger administration follows clinical standards for poor ovarian reserve patients when the leading follicle reaches 15 mm. Follicular volume will be measured on the trigger day and before oocyte pickup using a specialized ultrasound program that automatically calculates volume without extending procedure time. Oocyte pickup follows clinic standard operating procedures. During the study, participants will have ultrasounds to measure follicular volume alongside routine care. Researchers will track the correlation between follicular volume at trigger and oocyte maturity over one year. The study involves women aged 18 to 48 undergoing IVF with genetic testing, focusing on those with low antral follicle counts. This observational study monitors outcomes without altering standard treatment and is sponsored by ART Fertility Clinics LLC.

Follicular Volume at the Time of Final Oocyte Maturation in Poor Responders, and Its Correlation With Oocyte Maturity