Actively Recruiting
The Fourth Left Atrial Appendage Occlusion Study
Led by Hamilton Health Sciences Corporation · Updated on 2026-03-12
4000
Participants Needed
127
Research Sites
313 weeks
Total Duration
On this page
Sponsors
H
Hamilton Health Sciences Corporation
Lead Sponsor
M
McMaster University
Collaborating Sponsor
AI-Summary
What this Trial Is About
LAAOS-4 aims to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.
CONDITIONS
Official Title
The Fourth Left Atrial Appendage Occlusion Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Persistent or permanent atrial fibrillation OR paroxysmal atrial fibrillation with a history of ischemic stroke or systemic embolism
- CHA2DS2-VASc stroke risk score of 4 or higher
- Treatment with oral anticoagulants (Vitamin K agonist or factor Xa inhibitor) for at least 90 days before enrollment
- No planned discontinuation of oral anticoagulants during the trial
- Able and willing to give informed consent
You will not qualify if you...
- Younger than 18 years
- Current left atrial appendage blood clot (thrombus)
- Previous left atrial appendage occlusion or removal
- Previous closure of atrial septal defect or patent foramen ovale
- Previous atrial fibrillation ablation without recurrent qualifying atrial fibrillation at least 30 days after
- Planned atrial fibrillation ablation within 90 days of enrollment
- Treatment with direct thrombin inhibitors
- Women of childbearing potential not agreeing to effective birth control
- Expected life expectancy less than 2 years
- Unable or unwilling to give informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 127 locations
1
Affinity Hospital dba Grandview Medical Center
Birmingham, Alabama, United States, 35243
Withdrawn
2
Arrhythmia Research Group
Jonesboro, Arkansas, United States, 72401
Actively Recruiting
3
Memorial Health Services
Fountain Valley, California, United States, 92708
Actively Recruiting
4
Loma Linda University Health
Loma Linda, California, United States, 92354
Actively Recruiting
5
Southern California Permanente Medical Group
Pasadena, California, United States, 91101
Actively Recruiting
6
Sutter Valley Hospitals dba Sutter Institute for Medical Research
Sacramento, California, United States, 95816
Actively Recruiting
7
JFK Medical Center Limited Partnership d/b/a HCA Florida JFK Hospital
Atlantis, Florida, United States, 33462
Actively Recruiting
8
St. Vincent's Health System
Jacksonville, Florida, United States, 32204
Actively Recruiting
9
Largo Medical Center, Inc. d/b/a HCA Florida Largo Medical Center
Largo, Florida, United States, 33770
Actively Recruiting
10
The University of South Florida
Tampa, Florida, United States, 33620
Actively Recruiting
11
Emory University
Atlanta, Georgia, United States, 30322
Actively Recruiting
12
St Luke's Regional Medical Center, Ltd
Boise, Idaho, United States, 83712
Actively Recruiting
13
Kootenai Health Inc.
Coeur d'Alene, Idaho, United States, 83814
Actively Recruiting
14
Northwestern University
Evanston, Illinois, United States, 60208
Actively Recruiting
15
Cardiovascular Medicine, PLLC and Unity Point Trinity Rock Island
Rock Island, Illinois, United States, 61201
Actively Recruiting
16
Community Health Network Inc.
Indianapolis, Indiana, United States, 46256
Actively Recruiting
17
MercyOne Iowa Heart Center
West Des Moines, Iowa, United States, 50266
Actively Recruiting
18
University of Kansas Medical Center Research Institute, Inc.
Kansas City, Kansas, United States, 66160
Actively Recruiting
19
Babtist Health Lexington
Lexington, Kentucky, United States, 40503
Actively Recruiting
20
Ochsner Clinic Foundation
New Orleans, Louisiana, United States, 70121
Actively Recruiting
21
University of Maryland Baltimore
Baltimore, Maryland, United States, 21201
Actively Recruiting
22
Lahey Clinic Inc.
Burlington, Massachusetts, United States, 01805
Actively Recruiting
23
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
24
Henry Ford Health System
Detroit, Michigan, United States, 48202
Actively Recruiting
25
Henry Ford Health System
Detroit, Michigan, United States, 48202
Actively Recruiting
26
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
27
Hackensack University Medical Center
Hackensack, New Jersey, United States, 07601
Actively Recruiting
28
The Feinstein Institutes for Medical Research
Manhasset, New York, United States, 11030
Actively Recruiting
29
Cornell University for and on behalf of its Joan & Sanford I. Weill Medical College and The New York Presbyterian Hospital
New York, New York, United States, 10065
Actively Recruiting
30
NYU Grossman School of Medicine
New York, New York, United States, 10065
Withdrawn
31
Mission Hospital HCA
Asheville, North Carolina, United States, 28801
Actively Recruiting
32
Aultman Hospital
Canton, Ohio, United States, 44710
Actively Recruiting
33
TriHealth Inc.
Cincinnati, Ohio, United States, 45202
Actively Recruiting
34
University of Cincinnati
Cincinnati, Ohio, United States, 45221
Actively Recruiting
35
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
36
Saint Francis Hospital
Tulsa, Oklahoma, United States, 74136
Actively Recruiting
37
The Pennsylvania State University and The Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
38
The Trustees of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
39
University of Pittsburgh Medical Center (UPMC) Presbyterian Heart and Vascular Institute
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
40
Rhode Island Hospital
Providence, Rhode Island, United States, 02903
Actively Recruiting
41
Glanecare, Inc. d/b/a HCA Florida Brandon Hospital
Brentwood, Tennessee, United States, 37027
Actively Recruiting
42
Texas Cardiac Arrhythmia Research Foundation
Austin, Texas, United States, 78705
Withdrawn
43
Baylor Research Institute
Dallas, Texas, United States, 75204
Actively Recruiting
44
Heart Rhythm Associates
The Woodlands, Texas, United States, 77380
Withdrawn
45
CHRISTUS Northeast Texas Health System
Tyler, Texas, United States, 75701-2263
Actively Recruiting
46
The Rector and Visitors of the University of Virginia
Charlottesville, Virginia, United States, 22903
Actively Recruiting
47
CommonSpirit Health Research Institute
Tacoma, Washington, United States, 98405
Actively Recruiting
48
The Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
49
Imeldaziekenhuis
Bonheiden, Antwerpen, Belgium, 2820
Actively Recruiting
50
AZORG vzw and Hartcentrum Aalst
Aalst, East-Flanders, Belgium, 9300
Actively Recruiting
51
ASBL CHU Helora - Hôpital de La Louvière - site Jolimont
La Louvière, Hainaut, Belgium, 7100
Actively Recruiting
52
CHR de la Citadelle
Liège, Liège, Belgium, 4000
Actively Recruiting
53
AZ Glorieux
Ronse, Oost-Vlaanderen, Belgium, 9600
Actively Recruiting
54
AZ Sint Jan Brugge AV
Bruges, West-Vlaanderen, Belgium, 8000
Actively Recruiting
55
AZ Delta VZW
Roeselare, West-Vlaanderen, Belgium, 8800
Actively Recruiting
56
Universitair Ziekenhuis Brussel
Brussels, Belgium, 1090
Actively Recruiting
57
University of Calgary
Calgary, Alberta, Canada, T2N 1N4
Actively Recruiting
58
Vancouver Coastal Health Authority
Vancouver, British Columbia, Canada, V5Z 1M9
Actively Recruiting
59
St. Boniface Hospital Inc.
Winnipeg, Manitoba, Canada, R2H 2A6
Actively Recruiting
60
Circulate Cardiac & Vascular Centre (CCVC)
Burlington, Ontario, Canada, L7M 1K9
Actively Recruiting
61
Cambridge Cardiac Care Inc.
Cambridge, Ontario, Canada, N1R 6V6
Actively Recruiting
62
Hamilton Health Sciences Corp
Hamilton, Ontario, Canada, L8L 2X2
Actively Recruiting
63
Research St. Joseph's - Hamilton
Hamilton, Ontario, Canada, L8N 4A6
Actively Recruiting
64
Waterloo Wellington Cardiovascular Research Institute (WWCRI)
Kitchener, Ontario, Canada, N2M 5N6
Actively Recruiting
65
Lawson Health Research Institute
London, Ontario, Canada, N6A 2R5
Actively Recruiting
66
Southlake Regional Health Centre
Newmarket, Ontario, Canada, L2Y 2P9
Actively Recruiting
67
Partners in Advanced Cardiac Evaluation (PACE)
Newmarket, Ontario, Canada, L3Y 2P6
Actively Recruiting
68
Ottawa Heart Institute Research Corp
Ottawa, Ontario, Canada, K1Y 4W7
Actively Recruiting
69
Niagara Health System - Niagara Falls
St. Catharines, Ontario, Canada, L2S 0A9
Actively Recruiting
70
Niagara Health Systems - St. Catharines
St. Catharines, Ontario, Canada, L2S 0A9
Actively Recruiting
71
Sunnybrook Health Sciences Center
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
72
Lawrence Park Cardiology
Toronto, Ontario, Canada, M4N 3N1
Actively Recruiting
73
Unity Health Toronto
Toronto, Ontario, Canada, M5B 1W8
Actively Recruiting
74
Institut de Cardiologie de Montreal (ICM)
Montreal, Quebec, Canada, H1T 1C8
Actively Recruiting
75
Centre hospitalier de l'Université de Montréal
Montreal, Quebec, Canada, H2X OC1
Actively Recruiting
76
Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval
Québec, Quebec, Canada, G1V 4G5
Actively Recruiting
77
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke (CIUSSS de l'Estrie - CHUS)
Sherbrooke, Quebec, Canada, J1J 3H5
Actively Recruiting
78
Prairie Valscular Research Inc. (PVRI)
Regina, Saskatchewan, Canada, S4P 0W5
Actively Recruiting
79
Saskatchewan Health Authority
Saskatoon, Saskatchewan, Canada, S7K 0M7
Actively Recruiting
80
Region Hospital Viborg
Viborg, Central Jutland, Denmark, 8800
Actively Recruiting
81
Aarhus University Hospital (AUH)
Aarhus, Region Midt, Denmark, 8200
Actively Recruiting
82
Esbjerg & Grindsted Hospital - University Hospital of Southern Denmark
Esbjerg, Region Syddanmark, Denmark, 6700
Actively Recruiting
83
Rigshospitalet (RH)
Copenhagen, Denmark, 2100
Actively Recruiting
84
North Denmark Regional Hospital
Hjørring, Denmark, 9800
Actively Recruiting
85
Odense Universitets Hospital
Odense C, Denmark, 4500
Actively Recruiting
86
Infirmerie Protestante de Lyon
Caluire-et-Cuire, Auvergne-Rhône-Alpes, France, 69300
Actively Recruiting
87
CHU Saint Etienne
Saint-Etienne, Auvergne-Rhône-Alpes, France, 42055
Actively Recruiting
88
Centre Hospitalier Régional Universitaire de Tours
Tours, Centre-Val de Loire, France, 37044
Actively Recruiting
89
Clinique Pasteur
Toulouse, Occitanie, France, 31076
Actively Recruiting
90
SCP des Médecins Cardiologues
Toulouse, Occitanie, France, 31076
Actively Recruiting
91
L'Assistance Publique-Hôpitaux de Marseille
Marseille, Provence-Alpes-Côte d'Azur Region, France, 13005
Actively Recruiting
92
Hôpital Pitie Salpétrière
Paris, France, 75013
Actively Recruiting
93
Institut Médico-chirurgical Montsouris
Paris, France, 75014
Actively Recruiting
94
Hôpital Bichat
Paris, France, 75018
Actively Recruiting
95
European Georges Pompidou Hospital
Paris, France, 75908
Actively Recruiting
96
Hospital Prive Jacques Cartier
Massy, Île-de-France Region, France, 91300
Actively Recruiting
97
Centre Cardiologique due Nord
Saint-Denis, Île-de-France Region, France, 93200
Actively Recruiting
98
Städtisches Klinikum Karsruhe gGmbH
Karlsruhe, Baden-Wurttemberg, Germany, 76133
Actively Recruiting
99
Kardiovaskulaeres Zentrum Darmstadt
Darmstadt, Hesse, Germany, 64287
Actively Recruiting
100
CVC Rhein-Main GmbH
Frankfurt am Main, Hesse, Germany, 60389
Actively Recruiting
101
MVZ CCB Frankfurt und Main-Taunus GbR
Frankfurt am Main, Hesse, Germany, 60431
Actively Recruiting
102
Johann Wolfgang Goethe Universität Franfurt - Universitätsklinikum Franfurt
Frankfurt am Main, Hesse, Germany, 60590
Actively Recruiting
103
Krankenhausbetriebsgesellschaft Bad Oeynhausen mbH
Bad Oeynhausen, North Rhine-Westphalia, Germany, 32545
Actively Recruiting
104
Westpfalz-Klinikum GmbH
Kaiserslautern, Rhineland-Palatinate, Germany, 67665
Actively Recruiting
105
Herzzentrum Leipzig GmbH
Leipzig, Saxony, Germany, 04289
Actively Recruiting
106
Universitätsklinikum Schleswig - Holstein
Lübeck, Schleswig-Holstein, Germany, 23538
Actively Recruiting
107
Katholisches Krankenhaus "St. Johann Nepomuk"
Erfurt, Thuringia, Germany, 99097
Actively Recruiting
108
Charité Universitätsmedizin Berlin
Berlin, Germany, 10117
Actively Recruiting
109
Charité - Universitätsmedizin Berlin
Berlin, Germany, 12203
Actively Recruiting
110
Asklepios Kliniken Hamburg GmbH
Hamburg, Germany, 20099
Actively Recruiting
111
Asklepios Kliniken Hamburg GmbH
Hamburg, Germany, 20099
Actively Recruiting
112
Universitätsklinikum Hamburg-Eppendorf (UKE)
Hamburg, Germany, 20246
Actively Recruiting
113
Universitätsklinikum Heidelberg
Heidelberg, Germany, 69120
Actively Recruiting
114
Fondazione Poliambulanza Istituto Ospedaliero
Brescia, Italy, 25124
Actively Recruiting
115
Stichting Catharina Ziekenhuis
Eindhoven, North Brabant, Netherlands, 5623EJ
Actively Recruiting
116
American Heart of Poland SA
Ustroń, Poland, 43-450
Actively Recruiting
117
Hospital Álvaro Cunqueiro
Vigo, Pontevedra, Spain, 36312
Actively Recruiting
118
University General Hospital Dr. Balmis
Alicante, Spain, 03010
Actively Recruiting
119
Complejo Asistencial Universitario de León
León, Spain, 24071
Actively Recruiting
120
Universitario La Luz - Grupo Quirónsalud
Madrid, Spain, 28003
Actively Recruiting
121
Hospital Clínico Universitario de Valladolid
Valladolid, Spain, 47003
Actively Recruiting
122
University Hospitals of Leicester NHS Trust
Leicester, Leicestershire, United Kingdom, LE1 5WW
Actively Recruiting
123
Oxford University Hospitals NHS Foundation Trust
Oxford, Oxfordshire, United Kingdom, OX3 9DU
Actively Recruiting
124
University Hospitals Coventry and Warwickshire
Coventry, West Midlands, United Kingdom, CV2 2DX
Actively Recruiting
125
University Hospitals Sussex NHS Trust
Worthing, West Sussex, United Kingdom, BN11 2DH
Actively Recruiting
126
Liverpool Heart and Chest Hospital NHS Foundation Trust
Liverpool, United Kingdom, L14 3PE
Actively Recruiting
127
University Hospital Southampton NHS Foundation Trust
Southampton, United Kingdom, SO16 6YD
Actively Recruiting
Research Team
P
Program Director
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here