Actively Recruiting
Assessment of Frailty, Physical Capacity and Lung Function in Postoperative Cardiac Surgery Patients: an Observational and Prospective Clinical Study
Led by University of Sao Paulo General Hospital · Updated on 2025-03-28
200
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are examining how physical performance, lung function, and muscle strength change in patients after undergoing coronary artery bypass grafting (CABG) and heart valve replacement surgeries. This observational and prospective study focuses on adults aged 18 and older who are scheduled for these elective cardiac surgeries. The study aims to understand the effects of surgery on frailty, muscle and lung function, and to identify factors that might predict functional loss and mortality during hospitalization. Participants will be assessed before surgery, immediately after discharge from the intensive care unit (ICU), and again before hospital discharge, with an average study period of 15 days. Evaluations include physical performance tests such as the Short Physical Performance Battery (SPPB), the Six-Minute Walk Test, and the 1-minute sit-to-stand test. Muscle strength is measured using dynamometry and manovacuometry, while lung function is assessed via spirometry. Frailty will be assessed using the Clinical Frailty Scale (CFS). Throughout the study, participants will undergo multiple assessments to track changes in their physical and respiratory function at key time points: one day before surgery, the day after ICU discharge, and near the end of their hospital stay. Researchers will monitor hemodynamic and respiratory responses during physical tests and explore preoperative and postoperative risk factors. This comprehensive evaluation aims to provide insights into recovery patterns and help predict outcomes for cardiac surgery patients.
CONDITIONS
Brief Title
Frailty, Physical Capacity and Lung Function in Postoperative Cardiac Surgery Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 2 18 years
- Both genders
- Scheduled for elective coronary artery bypass grafting surgery
- Scheduled for elective heart valve surgery
- No cognitive or peripheral motor impairments preventing functional tests before surgery
You will not qualify if you...
- Surgeries performed via lateral thoracotomy or minithoracotomy
- Reoperation for any reason
- Cognitive or peripheral motor impairments preventing functional tests after surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) before surgery
Duration - Few days post-surgery until ICU discharge
Participants undergo myocardial revascularization or valve replacement surgery and are assessed immediately after discharge from the intensive care unit.
Assessments on the day immediately after ICU discharge
Duration - Up to approximately 15 days after surgery
Participants are observed and evaluated for changes in physical performance, lung function, frailty, and muscle strength during the postoperative period until hospital discharge.
Assessments before hospital discharge averaging 15 days post-surgery
Trial Site Locations
Total: 1 location
1
Instituto do Coração - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
São Paulo, São Paulo, Brazil, 05403-000
Actively Recruiting
Research Team
R
Rafael M Ianotti, PT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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