Gestational Diabetes Mellitus and Its Consequences in Mothers and Offsprings

What this Trial Is About

Gestational diabetes mellitus (GDM) is a common pregnancy disorder linked to both immediate and long-term health effects for mothers and their children. This research aims to follow a group of mothers with GDM and their offspring to study these outcomes, including fetal malformations like congenital heart diseases, birth weight, preterm birth, delivery method, growth and neurodevelopment after birth, and risks of obesity, type 2 diabetes, lung health, and allergic diseases in children. It also investigates future type 2 diabetes and cardiovascular risk factors in mothers after delivery. The study collects biological samples such as blood and tissue from mothers and children during pregnancy and after birth. It establishes a cohort for ongoing observation of maternal and child health over time. The goal includes identifying high-risk mother-child pairs to help improve targeted interventions and resource use. This observational study involves systematic follow-up to understand how GDM progresses to diabetes and related conditions. Participants will undergo assessments at multiple ages, including 6 months, 1 year, 3 years, 6 years, 12 years, and 18 years for children, and up to 18 years after delivery for mothers. Researchers will measure changes in obesity, type 2 diabetes status, body composition, depression symptoms, neurodevelopment, lung function, and allergic disease status. The study monitors these outcomes through clinical data collection and sample analysis, with the overall study period extending until 2038.

GDM and Its Consequences in Mothers and Offsprings