Actively Recruiting
A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC
Led by AstraZeneca · Updated on 2026-04-23
860
Participants Needed
264
Research Sites
449 weeks
Total Duration
On this page
Sponsors
A
AstraZeneca
Lead Sponsor
A
Arcus Biosciences, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a Phase III, randomised, double-blind, placebo-controlled, multicentre, international study assessing the efficacy and safety of durvalumab (MEDI4736) and domvanalimab (AB154) compared with durvalumab plus placebo in adults with locally advanced (Stage III), unresectable NSCLC whose disease has not progressed following definitive platinum-based cCRT.
CONDITIONS
Official Title
A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant must be 18 years or older at screening
- Histologically or cytologically confirmed non-small cell lung cancer treated with concurrent chemoradiation for locally advanced, unresectable (Stage III) disease
- Provision of a tumor tissue sample obtained before chemoradiation therapy
- Documented tumor PD-L1 status of 1% or higher by central laboratory
- Documented EGFR and ALK wild-type status (local or central)
- No disease progression after definitive platinum-based concurrent chemoradiotherapy
- Received at least 2 cycles of platinum-based chemotherapy concurrent with radiation therapy
- Received a total radiation dose of 60 Gy ±10% (54 to 66 Gy) administered by intensity modulated or 3D-conforming radiotherapy
- WHO performance status of 0 or 1 at randomization
- Adequate organ and marrow function
You will not qualify if you...
- History of another primary malignancy, except for certain treated malignancies with no active disease and no treatment in the past 3 years, adequately resected non-melanoma skin cancer or lentigo maligna without disease, and adequately treated carcinoma in situ without disease
- Mixed small cell and non-small cell lung cancer histology
- Receipt of sequential chemoradiation therapy (not including induction) for locally advanced unresectable NSCLC
- Disease progression during platinum-based concurrent chemoradiation therapy
- Any unresolved toxicity greater than Grade 2 from prior chemoradiation therapy (excluding alopecia)
- Pneumonitis of Grade 2 or higher from prior chemoradiation therapy
- History of idiopathic pulmonary fibrosis, drug-induced or idiopathic pneumonitis; active non-chemoradiation therapy induced pneumonitis Grade 2 or higher; active pneumonia; active interstitial lung disease; active or recently treated pleural effusion; or current pulmonary fibrosis
- Active or prior autoimmune or inflammatory disorders (with exceptions)
- Active or chronic active Epstein-Barr virus infection at screening
- Use of immunosuppressive medication within 14 days before first dose of durvalumab
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 264 locations
1
Research Site
Chandler, Arizona, United States, 85224
Actively Recruiting
2
Research Site
Phoenix, Arizona, United States, 85054
Suspended
3
Research Site
Fountain Valley, California, United States, 92708
Actively Recruiting
4
Research Site
Santa Rosa, California, United States, 95403
Actively Recruiting
5
Research Site
Washington D.C., District of Columbia, United States, 20016
Actively Recruiting
6
Research Site
Jacksonville, Florida, United States, 32224
Suspended
7
Research Site
Orlando, Florida, United States, 32804
Actively Recruiting
8
Research Site
Saint Augustine, Florida, United States, 32086
Actively Recruiting
9
Research Site
Macon, Georgia, United States, 31217
Suspended
10
Research Site
Elmhurst, Illinois, United States, 60126
Suspended
11
Research Site
Maywood, Illinois, United States, 60153
Withdrawn
12
Research Site
Naperville, Illinois, United States, 60540
Withdrawn
13
Research Site
Louisville, Kentucky, United States, 40202
Suspended
14
Research Site
Baltimore, Maryland, United States, 21224
Actively Recruiting
15
Research Site
Silver Spring, Maryland, United States, 20910
Suspended
16
Research Site
Ann Arbor, Michigan, United States, 48106-0995
Actively Recruiting
17
Research Site
Detroit, Michigan, United States, 48202
Completed
18
Research Site
Minneapolis, Minnesota, United States, 55407
Actively Recruiting
19
Research Site
Rochester, Minnesota, United States, 55905
Suspended
20
Research Site
Reno, Nevada, United States, 89511
Actively Recruiting
21
Research Site
East Brunswick, New Jersey, United States, 08816
Actively Recruiting
22
Research Site
Florham Park, New Jersey, United States, 07932
Withdrawn
23
Research Site
Buffalo, New York, United States, 14221
Withdrawn
24
Research Site
Johnson City, New York, United States, 13790
Withdrawn
25
Research Site
Asheville, North Carolina, United States, 28805
Withdrawn
26
Research Site
Asheville, North Carolina, United States, 28806
Withdrawn
27
Research Site
Charlotte, North Carolina, United States, 28204
Withdrawn
28
Research Site
Winston-Salem, North Carolina, United States, 27157
Withdrawn
29
Research Site
Columbus, Ohio, United States, 43214
Actively Recruiting
30
Research Site
Columbus, Ohio, United States, 43219
Withdrawn
31
Research Site
Maumee, Ohio, United States, 43537
Actively Recruiting
32
Research Site
Oklahoma City, Oklahoma, United States, 73102
Actively Recruiting
33
Research Site
Pittsburgh, Pennsylvania, United States, 15212
Actively Recruiting
34
Research Site
Charleston, South Carolina, United States, 29401
Suspended
35
Research Site
Chattanooga, Tennessee, United States, 37404
Actively Recruiting
36
Research Site
Nashville, Tennessee, United States, 37203
Actively Recruiting
37
Research Site
Nashville, Tennessee, United States, 37232
Suspended
38
Research Site
Fort Sam Houston, Texas, United States, 78234
Actively Recruiting
39
Research Site
Kingwood, Texas, United States, 77339
Withdrawn
40
Research Site
Arlington, Virginia, United States, 22205
Actively Recruiting
41
Research Site
Fort Belvoir, Virginia, United States, 22060
Actively Recruiting
42
Research Site
Spokane Valley, Washington, United States, 99216
Actively Recruiting
43
Research Site
Appleton, Wisconsin, United States, 54911
Actively Recruiting
44
Research Site
Brussels, Belgium, 1160
Actively Recruiting
45
Research Site
Edegem, Belgium, 2650
Actively Recruiting
46
Research Site
Haine-Saint-Paul, Belgium, 7100
Actively Recruiting
47
Research Site
Leuven, Belgium, 3000
Actively Recruiting
48
Research Site
Liège, Belgium, 4000
Actively Recruiting
49
Research Site
Sint-Niklaas, Belgium, 9100
Actively Recruiting
50
Research Site
Barretos, Brazil, 14784-400
Active, Not Recruiting
51
Research Site
Londrina, Brazil, 86015-520
Actively Recruiting
52
Research Site
Porto Alegre, Brazil, 91350200
Actively Recruiting
53
Research Site
Porto Velho, Brazil, 76834-899
Active, Not Recruiting
54
Research Site
Rio de Janeiro, Brazil, 20231-050
Actively Recruiting
55
Research Site
Santo André, Brazil, 09060-650
Active, Not Recruiting
56
Research Site
São Paulo, Brazil, 01221-900
Actively Recruiting
57
Research Site
São Paulo, Brazil, 01236-030
Withdrawn
58
Research Site
São Paulo, Brazil, 01310-000
Withdrawn
59
Research Site
São Paulo, Brazil, 04556-100
Withdrawn
60
Research Site
Taubaté, Brazil, 12030-200
Active, Not Recruiting
61
Research Site
Calgary, Alberta, Canada, T2N 5G2
Actively Recruiting
62
Research Site
Kelowna, British Columbia, Canada, V1Y 5L3
Actively Recruiting
63
Research Site
Laval, Quebec, Canada, H7M 3L9
Actively Recruiting
64
Research Site
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
65
Research Site
Las Condes, Chile, 7560908
Actively Recruiting
66
Research Site
Port Montt, Chile, 5500243
Actively Recruiting
67
Research Site
Santiago, Chile, 7500713
Actively Recruiting
68
Research Site
Santiago, Chile, 7520426
Actively Recruiting
69
Research Site
Santiago, Chile, 7630370
Actively Recruiting
70
Research Site
Santiago, Chile, 8241479
Actively Recruiting
71
Research Site
Temuco, Chile, 4810218
Actively Recruiting
72
Research Site
Aix-en-Provence, France, 13616
Actively Recruiting
73
Research Site
Angers, France, 49055
Actively Recruiting
74
Research Site
Bobigny, France, 93000
Actively Recruiting
75
Research Site
Clermont-Ferrand, France, 63000
Withdrawn
76
Research Site
Lille, France, 59000
Actively Recruiting
77
Research Site
Paris, France, 75014
Actively Recruiting
78
Research Site
Pau, France, 6400
Actively Recruiting
79
Research Site
Quimper, France, 29000
Actively Recruiting
80
Research Site
Saint-Grégoire, France, 35760
Actively Recruiting
81
Research Site
Saint-Quentin, France, 02321
Actively Recruiting
82
Research Site
Vantoux, France, 57070
Actively Recruiting
83
Research Site
Villeurbanne, France, 69100
Actively Recruiting
84
Research Site
Berlin, Germany, 12351
Actively Recruiting
85
Research Site
Berlin-Zehlendorf, Germany, 14165
Actively Recruiting
86
Research Site
Braunschweig, Germany, 38114
Actively Recruiting
87
Research Site
Chemnitz, Germany, 09116
Actively Recruiting
88
Research Site
Cologne, Germany, 51109
Actively Recruiting
89
Research Site
Erlangen, Germany, 91054
Actively Recruiting
90
Research Site
Essen, Germany, 45147
Actively Recruiting
91
Research Site
Georgsmarienhütte, Germany, 49124
Withdrawn
92
Research Site
Giessen, Germany, 35392
Actively Recruiting
93
Research Site
Halle, Germany, 06120
Actively Recruiting
94
Research Site
Hamburg, Germany, 21075
Withdrawn
95
Research Site
Homburg, Germany, 66421
Withdrawn
96
Research Site
Koblenz, Germany, 56073
Actively Recruiting
97
Research Site
Krefeld, Germany, 47805
Actively Recruiting
98
Research Site
Löwenstein, Germany, 74245
Actively Recruiting
99
Research Site
Moers, Germany, 47441
Terminated
100
Research Site
München, Germany, 81675
Withdrawn
101
Research Site
Regensburg, Germany, 93049
Actively Recruiting
102
Research Site
Regensburg, Germany, 93053
Actively Recruiting
103
Research Site
Tübingen, Germany, 72076
Actively Recruiting
104
Research Site
Athens, Greece, 11526
Actively Recruiting
105
Research Site
Athens, Greece, 11527
Actively Recruiting
106
Research Site
Athens, Greece, 12462
Actively Recruiting
107
Research Site
Athens, Greece, 18547
Actively Recruiting
108
Research Site
Holargos, Athens, Greece, 155 62
Actively Recruiting
109
Research Site
Thessaloniki, Greece, 55236
Actively Recruiting
110
Research Site
Thessaloniki, Greece, 56 429
Actively Recruiting
111
Research Site
Thessaloniki, Greece, 57001
Actively Recruiting
112
Research Site
Hong Kong, Hong Kong, 150001
Actively Recruiting
113
Research Site
Budapest, Hungary, 1121
Actively Recruiting
114
Research Site
Budapest, Hungary, 1122
Actively Recruiting
115
Research Site
Deszk, Hungary, 6772
Actively Recruiting
116
Research Site
Győr, Hungary, 9024
Actively Recruiting
117
Research Site
Salgótarján, Hungary, 3100
Actively Recruiting
118
Research Site
Székesfehérvár, Hungary, 8000
Actively Recruiting
119
Research Site
Törökbálint, Hungary, 2045
Actively Recruiting
120
Research Site
Ahmedabad, India, 380054
Completed
121
Research Site
Bangalore, India, 560027
Actively Recruiting
122
Research Site
Bangalore, India, 560064
Actively Recruiting
123
Research Site
Delhi, India, 110085
Actively Recruiting
124
Research Site
Gurgaon, India, 122001
Withdrawn
125
Research Site
Howrah, India, 711103
Actively Recruiting
126
Research Site
Hyderabad, India, 500032
Actively Recruiting
127
Research Site
Jaipur, India, 302004
Actively Recruiting
128
Research Site
Jaipur, India, 302022
Actively Recruiting
129
Research Site
Kolkata, India, 700160
Actively Recruiting
130
Research Site
Marg Jaipur, India, 302004
Actively Recruiting
131
Research Site
Mohali, India, 160055
Completed
132
Research Site
Namakkal, India, 637001
Actively Recruiting
133
Research Site
New Delhi, India, 110005
Completed
134
Research Site
New Delhi, India, 110029
Actively Recruiting
135
Research Site
Varanasi, India, 221005
Actively Recruiting
136
Research Site
Bergamo, Italy, 24127
Actively Recruiting
137
Research Site
Roma, Italy, 00144
Actively Recruiting
138
Research Site
Rozzano, Italy, 20089
Actively Recruiting
139
Research Site
Udine, Italy, 33100
Withdrawn
140
Research Site
Bunkyō City, Japan, 113-8431
Actively Recruiting
141
Research Site
Bunkyō City, Japan, 113-8603
Actively Recruiting
142
Research Site
Bunkyō City, Japan, 113-8677
Actively Recruiting
143
Research Site
Chiba, Japan, 260-8717
Actively Recruiting
144
Research Site
Fukuoka, Japan, 812-8582
Actively Recruiting
145
Research Site
Hidaka-shi, Japan, 350-1298
Actively Recruiting
146
Research Site
Hirosaki-shi, Japan, 036-8563
Actively Recruiting
147
Research Site
Itabashi-ku, Japan, 173-0003
Actively Recruiting
148
Research Site
Kashihara-shi, Japan, 634-8522
Actively Recruiting
149
Research Site
Kōtoku, Japan, 135-8550
Actively Recruiting
150
Research Site
Kumamoto, Japan, 860-8556
Actively Recruiting
151
Research Site
Matsuyama, Japan, 791-0280
Actively Recruiting
152
Research Site
Nagoya, Japan, 464-8681
Actively Recruiting
153
Research Site
Osaka, Japan, 545-8586
Actively Recruiting
154
Research Site
Osakasayama-shi, Japan, 589-8511
Actively Recruiting
155
Research Site
Sapporo, Japan, 003-0804
Actively Recruiting
156
Research Site
Sunto-gun, Japan, 411-8777
Actively Recruiting
157
Research Site
Tokyo, Japan, 104-0045
Actively Recruiting
158
Research Site
Yokohama, Japan, 221-0855
Actively Recruiting
159
Research Site
Yokohama, Japan, 241-8515
Actively Recruiting
160
Research Site
Johor Bahru, Malaysia, 81100
Actively Recruiting
161
Research Site
Kuala Lumpur, Malaysia, 59100
Actively Recruiting
162
Research Site
Kuala Selangor, Malaysia, 46050
Actively Recruiting
163
Research Site
Kuching, Malaysia, 93586
Actively Recruiting
164
Research Site
Aguascalientes, Mexico, 20230
Withdrawn
165
Research Site
Chihuahua City, Mexico, 31207
Actively Recruiting
166
Research Site
Guadalajara, Mexico, 44280
Withdrawn
167
Research Site
Guadalajara, Mexico, 44638
Actively Recruiting
168
Research Site
Mexico City, Mexico, 03810
Actively Recruiting
169
Research Site
Monterrey, Mexico, 64460
Withdrawn
170
Research Site
Oaxaca City, Mexico, 68020
Actively Recruiting
171
Research Site
San Pedro Garza García, Mexico, 66220
Withdrawn
172
Research Site
Sonora, Mexico, 83207
Withdrawn
173
Research Site
Veracruz, Mexico, 91900
Withdrawn
174
Research Site
Bodø, Norway, 8092
Actively Recruiting
175
Research Site
Gjøvik, Norway, 2819
Actively Recruiting
176
Research Site
Oslo, Norway, 0379
Actively Recruiting
177
Research Site
Trondheim, Norway, 0730
Actively Recruiting
178
Research Site
Bacolod, Philippines, 6100
Withdrawn
179
Research Site
City of Muntinlupa, Philippines, 1780
Actively Recruiting
180
Research Site
Iloilo City, Philippines, 5000
Actively Recruiting
181
Research Site
Manila, Philippines, 1000
Not Yet Recruiting
182
Research Site
Pasig, Philippines, 1605
Withdrawn
183
Research Site
Quezon City, Philippines, 1100
Actively Recruiting
184
Research Site
Quezon City, Philippines, 1112
Actively Recruiting
185
Research Site
Bialystok, Poland, 15-027
Actively Recruiting
186
Research Site
Gliwice, Poland, 44-102
Withdrawn
187
Research Site
Gliwice, Poland, 44-102
Actively Recruiting
188
Research Site
Katowice, Poland, 40-074
Completed
189
Research Site
Lodz, Poland, 93-513
Actively Recruiting
190
Research Site
Warsaw, Poland, 02-781
Actively Recruiting
191
Research Site
Wroclaw, Poland, 53-413
Actively Recruiting
192
Research Site
Zielona Góra, Poland, 65-046
Withdrawn
193
Research Site
Bucharest, Romania, 022328
Completed
194
Research Site
Bucharest, Romania, 050098
Completed
195
Research Site
Craiova, Romania, 200542
Actively Recruiting
196
Research Site
Floreşti, Romania
Actively Recruiting
197
Research Site
Iași, Romania, 700483
Actively Recruiting
198
Research Site
Oradea, Romania, 410001
Actively Recruiting
199
Research Site
Sibiu, Romania, 550245
Actively Recruiting
200
Research Site
Suceava, Romania, 720214
Completed
201
Research Site
Timișoara, Romania, 300166
Withdrawn
202
Research Site
Cape Town, South Africa, 7570
Withdrawn
203
Research Site
eManzimtoti, South Africa, 4126
Withdrawn
204
Research Site
eManzimtoti, South Africa, 4126
Completed
205
Research Site
Johannesburg, South Africa, 2196
Withdrawn
206
Research Site
Parktown, South Africa, 2193
Terminated
207
Research Site
Pretoria, South Africa, 0084
Active, Not Recruiting
208
Research Site
Daegu, South Korea, 42415
Actively Recruiting
209
Research Site
Goyang-si, South Korea, 10408
Actively Recruiting
210
Research Site
Incheon, South Korea, 21431
Actively Recruiting
211
Research Site
Incheon, South Korea, 21565
Actively Recruiting
212
Research Site
Jinju, South Korea, 52727
Actively Recruiting
213
Research Site
Seoul, South Korea, 02841
Withdrawn
214
Research Site
Seoul, South Korea, 03722
Actively Recruiting
215
Research Site
Seoul, South Korea, 06273
Actively Recruiting
216
Research Site
Seoul, South Korea, 06351
Actively Recruiting
217
Research Site
Seoul, South Korea, 07061
Actively Recruiting
218
Research Site
Suwon, South Korea, 16247
Actively Recruiting
219
Research Site
Bilbao (Vizcaya), Spain, 48013
Actively Recruiting
220
Research Site
Castellon, Spain, 12002
Actively Recruiting
221
Research Site
Córdoba, Spain, 14004
Actively Recruiting
222
Research Site
El Palmar, Spain, 30120
Actively Recruiting
223
Research Site
Palma de Mallorca, Spain, 07010
Actively Recruiting
224
Research Site
Sabadell (Barcelona), Spain, 08208
Actively Recruiting
225
Research Site
Basel, Switzerland, 4031
Actively Recruiting
226
Research Site
Bern, Switzerland, CH-3010
Actively Recruiting
227
Research Site
Lausanne, Switzerland, 1011
Actively Recruiting
228
Research Site
Hsinchu, Taiwan, 300
Actively Recruiting
229
Research Site
New Taipei City, Taiwan, 220216
Actively Recruiting
230
Research Site
Taichung, Taiwan, 40447
Actively Recruiting
231
Research Site
Taichung, Taiwan, 40705
Actively Recruiting
232
Research Site
Tainan, Taiwan, 704
Actively Recruiting
233
Research Site
Taipei, Taiwan, 10002
Actively Recruiting
234
Research Site
Taipei, Taiwan, 10449
Actively Recruiting
235
Research Site
Taipei, Taiwan, 11217
Actively Recruiting
236
Research Site
Taoyuan, Taiwan, 333
Actively Recruiting
237
Research Site
Bangkok, Thailand, 10300
Actively Recruiting
238
Research Site
Bangkok, Thailand, 10400
Actively Recruiting
239
Research Site
Bangkok, Thailand, 10700
Actively Recruiting
240
Research Site
Hat Yai, Thailand, 90110
Actively Recruiting
241
Research Site
Adapazarı, Turkey (Türkiye), 54290
Actively Recruiting
242
Research Site
Ankara, Turkey (Türkiye), 06340
Actively Recruiting
243
Research Site
Ankara, Turkey (Türkiye), 6100
Actively Recruiting
244
Research Site
Antalya, Turkey (Türkiye), 07058
Actively Recruiting
245
Research Site
Çankaya, Turkey (Türkiye), 06680
Actively Recruiting
246
Research Site
Edirne, Turkey (Türkiye), 22030
Actively Recruiting
247
Research Site
Istanbul, Turkey (Türkiye), 34098
Actively Recruiting
248
Research Site
Istanbul, Turkey (Türkiye), 34662
Actively Recruiting
249
Research Site
Izmir, Turkey (Türkiye), 35360
Actively Recruiting
250
Research Site
Konya, Turkey (Türkiye), 42080
Actively Recruiting
251
Research Site
Birmingham, United Kingdom, B9 5SS
Actively Recruiting
252
Research Site
Brighton, United Kingdom, BN2 5BE
Actively Recruiting
253
Research Site
Cambridge, United Kingdom, CB2 0QQ
Withdrawn
254
Research Site
Cardiff, United Kingdom, CF14 2TL
Actively Recruiting
255
Research Site
Cheltenham, United Kingdom, GL53 7AN
Actively Recruiting
256
Research Site
Edinburgh, United Kingdom, EH4 2XR
Actively Recruiting
257
Research Site
High Heaton/Newcastle Upon Tyn, United Kingdom, NE7 7DN
Actively Recruiting
258
Research Site
Leeds, United Kingdom, LS 9 7TF
Actively Recruiting
259
Research Site
London, United Kingdom, SE1 9RT
Actively Recruiting
260
Research Site
Nottingham, United Kingdom, NG5 1PB
Actively Recruiting
261
Research Site
Truro, United Kingdom, TR1 3LJ
Actively Recruiting
262
Research Site
Hanoi, Vietnam, 100000
Actively Recruiting
263
Research Site
Hanoi, Vietnam, 10000
Actively Recruiting
264
Research Site
Ho Chi Minh City, Vietnam, 700000
Actively Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
A
AstraZeneca Lung Cancer Study Locator Service
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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