Investigation of Gut Leakage and Abdominal Ultrasound Changes in Adults Hospitalized with Dengue Infection

What this Trial Is About

Researchers are investigating intestinal barrier dysfunction, also known as gut leakage, in adults hospitalized with dengue infection. This study focuses on detecting the movement of gut-derived bacteria and their products into the bloodstream, which may trigger inflammation leading to severe dengue symptoms such as plasma leakage. The trial is conducted in a tertiary care hospital in Chattogram, Bangladesh, where dengue is a significant health concern. Participants include hospitalized adults with dengue, both severe and non-severe, along with healthy controls. Blood biomarkers related to gut permeability and microbial translocation will be measured at enrollment, with a second sample taken if non-severe patients develop severe symptoms. Abdominal ultrasound will assess gastrointestinal changes, and stool samples from some patients will be analyzed to study changes in intestinal microbiota. Throughout the study, participants will have blood tests at enrollment and on day 7 of illness, with stool collection for microbiota analysis from selected patients. Clinical events will be documented up to 28 days. Healthy controls will have one baseline visit for biomarker and ultrasound assessment. The study aims to correlate biochemical markers with ultrasound findings and disease severity, helping to understand the role of gut leakage in dengue progression.

Gut Leakage' in Dengue