Effects of Blackcurrant Supplements on Bone Health and Gut Microbiome in Postmenopausal Women A Randomized, Placebo-Controlled Trial Using Multi-Omics to Understand Bone Loss Prevention

What this Trial Is About

Researchers are evaluating the effects of blackcurrant BC supplementation on bone density and gut microbiome composition in postmenopausal females aged 45 to 70 years. This trial focuses on postmenopausal osteoporosis, a bone disorder caused by estrogen deficiency leading to bone loss. The study aims to understand how BC and gut microbiota interact to reduce bone loss using a multi-omics approach that examines immune, endocrine, genetic, and metabolic factors. Participants will be randomly assigned to one of three groups low-dose BC extract, high-dose BC extract, or placebo. Those in BC groups will consume three capsules daily containing varying amounts of BC extract, while the placebo group will consume capsules without BC. The intervention lasts 12 months, during which researchers will monitor bone density, biomarkers of bone remodeling, gut microbiome changes, and various protein, metabolite, and genetic markers. During the study, participants will undergo three blood draws, three stool collections, and three bone scans to assess changes over time. Researchers will measure bone mineral density at several sites and analyze biomarkers related to bone health, immune and endocrine functions, and gut bacteria. The study includes careful monitoring of diet and exercise to support reliable results. Total participation spans one year with regular assessments to evaluate BCs potential impact on bone health and gut microbiota.

Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females