Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort study.
S Parvez, R R Gerona, C Proctor...
https://pubmed.ncbi.nlm.nih.gov/29519238Actively Recruiting
Age: 18Years +
FEMALE
Healthy Volunteers
ID05492708
Children's Health in the Heartland Study
Led by Heartland Health Research Alliance · Updated on 2025-06-29
2600
Participants Needed
4
Research Sites
104 weeks
Total Duration
On this page
Sponsors
H
Heartland Health Research Alliance
Lead Sponsor
I
Indiana University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Heartland Study is a prospective observational research project enrolling up to 2,600 pregnant participants across the Heartland States in the U.S. It aims to fill important knowledge gaps about how herbicide exposure affects maternal and infant health. Researchers will examine links between environmental herbicide exposure during and after pregnancy and outcomes related to reproduction, childbirth, and child development, including epigenetic biomarkers of exposure. During the first phase, pregnant participants up to 20 weeks and 6 days gestation will be enrolled and followed through to the end of pregnancy. Urine and cheek cell samples will be collected to measure herbicide exposure and identify related epigenetic changes. The study will also gather information through questionnaires about food and drink habits, chemical exposures at work and home, substance use, living near agricultural fields, and socioeconomic factors. Participants will have their pregnancy outcomes and fetal health tracked and analyzed to explore potential effects of herbicide exposure on the fetus. Researchers will monitor pregnancy loss, preterm birth, and hypertensive disorders up to 12 weeks after delivery. The study includes questionnaires and biological sample collection during pregnancy to assess exposure and health outcomes. Overall participation lasts through pregnancy and shortly after delivery, providing comprehensive data on maternal and infant health in relation to herbicide exposure.
CONDITIONS
Brief Title
The Heartland Study
Who Can Participate
Age: 18Years +
FEMALE
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Pregnant persons aged 18 years or older at time of consent who are less than or equal to 20 weeks and 6 days pregnant
- Enrollment in the first trimester (less than or equal to 13 weeks and 6 days) is preferred but not required
- Living in one of the 13 Heartland Study region states: Arkansas, Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, or Wisconsin
- Optional inclusion of the putative biological father
You will not qualify if you...
- Participants who are not fluent in and/or do not fully understand, read, write, or speak the English language
- Inability to provide informed consent to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote)
Monitoring
Duration - From enrollment through delivery
Participants are followed through pregnancy to document pregnancy outcomes and fetal health, including collection of prenatal urine and cheek samples, questionnaires on environmental exposures, and indirect measures such as food and beverage consumption and residential proximity to agricultural fields.
Multiple visits timed with pregnancy milestones
Long-term Monitoring
Duration - Up to 12 weeks after delivery
Participants are monitored for up to twelve weeks after delivery to assess hypertensive disorders of pregnancy and other outcomes.
Approximately 2 to 3 follow-up visits postpartum
Trial Site Locations
Total: 4 locations
1
Indiana University Medical Center
Indianapolis, Indiana, United States, 46202
Actively Recruiting
2
University of Iowa Health Care
Iowa City, Iowa, United States, 52242
Actively Recruiting
3
Gundersen Health
La Crosse, Wisconsin, United States, 54601
Completed
4
Marshfield Clinic
Marshfield, Wisconsin, United States, 54449
Actively Recruiting
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Research Team
K
Kathleen Flannery
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Perinatal health effects of herbicides exposures in the United States: the Heartland Study, a Midwestern birth cohort study.
Marlaina Freisthler, Paul W Winchester, Heather A Young...
https://pubmed.ncbi.nlm.nih.gov/37993831