Actively Recruiting
The Heartland Study
Led by Heartland Health Research Alliance · Updated on 2025-06-29
2600
Participants Needed
4
Research Sites
468 weeks
Total Duration
On this page
Sponsors
H
Heartland Health Research Alliance
Lead Sponsor
I
Indiana University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Heartland Study is a prospective, observational study that will enroll up to 2,600 pregnant participants across the Heartland States in the U.S.. The objective of the Heartland Study is to address major knowledge gaps concerning the health effects of herbicides on maternal and infant health. The study is being conducted to evaluate the associations between environmental exposures to herbicides during and after pregnancy and reproductive health outcomes. The study is measuring multiple biomarkers of herbicide exposure among pregnant Midwesterners and their partners to evaluate associations with pregnancy and childbirth outcomes, epigenetic biomarkers of exposure, and child development.
CONDITIONS
Official Title
The Heartland Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pregnant persons aged 18 years or older at time of consent who are less than or equal to 20 weeks and 6 days pregnant
- Enrollment based on best clinical estimate of gestational age
- Preference for enrollment in first trimester (less than or equal to 13 weeks and 6 days), but anyone less than or equal to 20 weeks and 6 days is allowed
- Living in one of the 13 Heartland Study region states: Arkansas, Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Nebraska, North Dakota, Ohio, South Dakota, or Wisconsin
- Optional inclusion of the putative biological father
You will not qualify if you...
- Not fluent in or unable to fully understand, read, write, or speak English
- Inability to provide informed consent to participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Indiana University Medical Center
Indianapolis, Indiana, United States, 46202
Actively Recruiting
2
University of Iowa Health Care
Iowa City, Iowa, United States, 52242
Actively Recruiting
3
Gundersen Health
La Crosse, Wisconsin, United States, 54601
Completed
4
Marshfield Clinic
Marshfield, Wisconsin, United States, 54449
Actively Recruiting
Research Team
K
Kathleen Flannery
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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