Actively Recruiting
Hemodiafiltration Versus Hemodialysis in Older People
Led by AUB Santé · Updated on 2026-02-23
62
Participants Needed
4
Research Sites
43 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will compare the impact of two hemodialysis techniques on fatigue and post-dialysis recovery time in patients aged 85 years and older. These two techniques are high-flux hemodialysis (HD) and hemodiafiltration (HDF). Patients will receive the treatment over two periods: if period 1 is HD then period 2 will be HDF. Every patient will be his/her own control, this is why it is called cross-over. Each period will last three months. Between the two periods, patients will receive a traditional low-flux hemodialysis. These two techniques are widely used worldwide and their side-effects are well-known and do not put the patients at risk. HDF has been shown to improve survival in patients with a mean age of 58 years. But a previous study from the investigators' group showed that HDF causes a prolonged recovery time in older patients. This randomized trial aims to elucidate this question.
CONDITIONS
Official Title
Hemodiafiltration Versus Hemodialysis in Older People
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent
- Age over 84 years
- Diagnosed with kidney failure
- On maintenance hemodialysis for more than 3 months
- Willing to have dialysis sessions lasting 3.5 to 4 hours, three times a week
- Has a reliable vascular access
- Covered by health insurance
You will not qualify if you...
- Patients with cognitive impairment (assessed with a mini-test if needed)
- Hospitalized at inclusion
- Difficulties with speaking French
- Terminally ill with life expectancy less than 3 months
- Active cancer
AI-Screening
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Trial Site Locations
Total: 4 locations
1
AUB Santé
Bretagne, France
Actively Recruiting
2
AIDER
Grabels, France, 34790
Actively Recruiting
3
ECHO
Le Mans, France
Actively Recruiting
4
Aura Paris
Paris, France
Actively Recruiting
Research Team
M
Mabel AOUN, M.D., M.P.H.
CONTACT
S
Sibylle Gourvil
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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