Actively Recruiting
Hepatic Histopathology in Urea Cycle Disorders
Led by Baylor College of Medicine · Updated on 2025-07-20
70
Participants Needed
2
Research Sites
226 weeks
Total Duration
On this page
Sponsors
B
Baylor College of Medicine
Lead Sponsor
C
Children's National Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a multi-site, retrospective chart review as well as a prospective study to evaluate histopathologic findings in liver samples from individuals with any UCD diagnosis. This study will be conducted at all Urea Cycle Disorders Consortium (UCDC) sites: Baylor College of Medicine in Houston, TX and Children's National Medical Center in Washington D.C.
CONDITIONS
Official Title
Hepatic Histopathology in Urea Cycle Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of primary urea cycle disorder confirmed by enzyme activity, DNA testing, or metabolite analysis
- History of liver transplantation and/or liver biopsy OR planned liver transplantation and/or liver biopsy
You will not qualify if you...
- No available histopathology report or liver tissue/slides from biopsy or explant
- Expected inability to obtain pathology report, liver tissue blocks, or pathology slides after liver biopsy or transplantation
- Known secondary liver diseases such as chronic viral hepatitis, autoimmune liver disease, short gut, small bowel syndrome, alcohol liver disease, or TPN-related cholestatic disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010
Not Yet Recruiting
2
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
S
Saima Ali, MSN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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