Human Upper Extremity Allotransplantation: Transplanted Patient Follow-Up Protocol

What this Trial Is About

Researchers are studying the long-term outcomes of upper extremity allotransplantation, a procedure where a transplanted hand or arm is attached to a patient. This research is important to monitor the safety of the surgery and the immunosuppressive treatments used to prevent rejection. The study aims to collect ongoing data to better understand patient quality of life and functional outcomes following this complex transplant. The study involves follow-up assessments of patients who have undergone unilateral or bilateral upper limb transplantation at least five years prior. Participants agree to ongoing monitoring, including sample collection like biopsies, and adherence to immunomodulatory treatment plans. The research team evaluates various measures of hand function, psychological well-being, and physical health over approximately five years post-enrollment. Participants will have regular evaluations using questionnaires assessing hand function, pain, psychological health, and quality of life. Additional tests include antibody monitoring, skin biopsies, CT angiography, and MR neurography, performed annually for five years. These assessments help researchers track changes from baseline to understand the impact of transplantation and treatments. Patient commitment to the protocol and immunosuppressive therapy is required throughout the study period.

Human Upper Extremity Allotransplantation: F/U Protocol