HUmanitas Proton Therapy Study for Adults with Solid Tumors Observational Research on Treatment Outcomes and Safety

What this Trial Is About

Proton therapy is a cancer treatment similar to standard radiation therapy but uses unique particles that may reduce side effects and improve disease control. This trial focuses on collecting data to support the development and safety of proton therapy, which is currently available only for select diseases in Italy following national guidelines. The study is observational and aims to gather real-world information over an extended period. Participants in this study will receive proton therapy as part of their clinical care based on medical indications. The therapy is administered according to standard practice without experimental modifications. This study does not compare proton therapy to other treatments but observes outcomes from patients treated with this method. During the study, researchers will collect data from enrollment through 10 years, monitoring treatment side effects, identifying biomarkers, optimizing treatment planning, assessing secondary cancer risks, and evaluating quality of life. Participants will be followed long term to observe treatment adherence, outcomes in rare tumors, and overall safety. The total participation time may extend up to 10 years for comprehensive data collection.

HUmanitas PROtontherapy (HU-PRO)