Actively Recruiting
Composite Autonomic Scoring Scale and Head-Up Tilt Test to Assess Cardiac Autonomic Nervous Function: A Preliminary Study
Led by The First Hospital of Hebei Medical University · Updated on 2024-09-26
1122
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Autonomic nervous system diseases can disrupt the circulatory system and may lead to dangerous heart rhythm problems and sudden cardiac death. This research focuses on finding clear, practical diagnostic methods to evaluate the function of the autonomic nervous system, especially the heart's autonomic nerves. The study aims to support better evaluation through the use of the Head-Up Tilt Test (HUTT). The study analyzed 169 patient samples who underwent the vertical tilt test and 24-hour Holter electrocardiogram (ECG) data collected between February 13, 2023, and October 31, 2023. Researchers compared several heart rate variability indicators with the Composite Autonomic Scoring Scale (CASS) to identify those most closely related to sympathetic and vagus nerve functions. They then defined score intervals and analyzed the sensitivity and specificity of these indicators. Participants performed both the vertical tilt test and 24-hour Holter ECG simultaneously while receiving treatment at the hospital. Researchers examined heart rate variability and autonomic scoring data to evaluate cardiac autonomic nervous function. The primary outcome is to find the indicators most correlated with sympathetic and vagus nerves by December 31, 2025. This observational study includes participants aged 12 to 85 years and allows healthy volunteers to join.
CONDITIONS
Brief Title
HUTT to Assess Cardiac Autonomic Nervous Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have undergone both vertical tilt test and 24-hour Holter electrocardiogram at the same time
- Are receiving treatment at the hospital conducting the study
- Age between 12 and 85 years
You will not qualify if you...
- Taken benzodiazepines or blood pressure lowering drugs within the past 24 hours
- Have mental illness, severe dementia, or serious organ disease
- Have severe arrhythmia, breathing difficulties, or poor coordination affecting test results interpretation
- Conditions that interfere with Valsalva maneuver such as deep breathing problems or poor coordination of movements that affect results interpretation
- Severe arrhythmia impacting test results interpretation
- Serious organ diseases affecting participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo vertical tilt test and 24-hour Holter electrocardiogram to assess cardiac autonomic nervous function.
1 visit (in-person)
Duration - February 13, 2023 to December 31, 2025
Participants' autonomic nervous function indicators are monitored and analyzed over time to evaluate correlation with cardiac autonomic scores.
Follow-up assessments as per routine care
Trial Site Locations
Total: 1 location
1
The First Hospital Of Hebei Medical University
Shijiazhuang, Hebei, China, 050000
Actively Recruiting
Research Team
Y
Yan Ding, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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