Study on the Causes and Treatment Development for Squamous Cell Carcinomas of the Anogenital and Head-Neck Areas

What this Trial Is About

Researchers are investigating the underlying mechanisms of squamous cell carcinomas SCC affecting the mucous membranes of the anogenital tract and head-neck region. This multicenter study combines both retrospective and prospective approaches, including 170 patients from several institutions. The goal is to analyze molecular and viral biomarkers to better understand these cancers and to develop shared therapeutic strategies. The study involves collecting and examining tissue samples from past and current patients. Fibroblastic tumor-associated cells CAFs will be isolated from new samples and grown alongside immortalized cell lines to create 3D organoids. These organoids will be used to test responses to telomerase and SIRT1 deacetylase inhibitors in laboratory and preclinical experiments. Participants will provide samples that undergo multiparameter analysis for biomarkers. Researchers will study these markers over a 30-month period to evaluate primary and secondary outcomes. There is no intervention directly involving participants beyond sample collection and analysis. The study focuses on laboratory and preclinical assessments, without altering patient treatment, and will continue monitoring results through this timeframe.

Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas