Study on How Adrenal Incidentalomas and Possible Autonomous Cortisol Secretion Affect Heart and Metabolic Health Including Effects of Surgery or Conservative Treatment

What this Trial Is About

Researchers are investigating the effects of adrenal incidentalomas and possible autonomous cortisol secretion pACS on cardiovascular and metabolic health. The study focuses on patients with adrenal masses that may partially alter cortisol levels without clear symptoms of cortisol excess. It aims to understand how these conditions impact heart and metabolic functions and whether surgery or conservative management can improve patient outcomes. Participants include those with different adrenal conditions non-functioning adrenal adenomas, pACS managed conservatively, pACS treated with adrenalectomy following 2016 European Society of Endocrinology guidelines, and healthy individuals without adrenal masses. The study follows these groups over time to compare the effects of surgical and non-surgical approaches on health markers. Participants will undergo assessments at the start, one year, and five years later. These include heart ultrasound to check for left ventricular hypertrophy, blood pressure and arterial stiffness measurements, blood tests for coagulation and lipid profiles, bone density scans, and questionnaires evaluating sleep, infections, quality of life, depression, and sexual function. Researchers will monitor changes in insulin resistance, weight, and adrenal mass size throughout the study to better understand the cardiovascular and metabolic changes associated with these adrenal conditions.

Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations