Evaluating EEG-Guided Versus Standard Sevoflurane Anesthesia Effect on Opioid Use and Recovery in Children Undergoing Surgery Without Regional Anesthesia

What this Trial Is About

Researchers are evaluating how adjusting sevoflurane anesthesia based on electroencephalography EEG affects opioid use and recovery quality in children aged 2 to 8 years undergoing painful elective tonsillectomy or adenoidectomy without regional anesthesia. This randomized, single-blind trial compares standard sevoflurane dosing with EEG-guided titration to understand its impact on opioid consumption and emergence outcomes. Participants are assigned to one of two groups one receives fixed sevoflurane dosing at 1 age-adjusted MAC with the EEG screen concealed, while the other groups sevoflurane dose is adjusted to maintain a specific EEG pattern starting at about 0.7 MAC. Both groups receive fentanyl as needed based on pain signs. The study measures intraoperative opioid use, sevoflurane exposure, EEG changes, emergence time, delirium, postoperative pain, and hemodynamic events. During the trial, children undergo anesthesia with either standard or EEG-guided sevoflurane dosing and receive opioid administration if necessary. Researchers monitor EEG patterns, opioid consumption, emergence quality, and postoperative pain using scales like the PAED scale. Parental consent and child assent are obtained, and assessments include EEG spectral analysis. The study aims to provide insights into anesthesia management and recovery quality in pediatric surgery, with participation lasting through the surgery and immediate postoperative period.

Impact of EEG-guided Sevofluorane on Opioid Consumption and Quality of Awakening