Actively Recruiting
Impact of Varying Doses of Prucalopride on Improving Gut Function Recovery After Elective Colorectal Surgery
Led by Future University in Egypt · Updated on 2025-03-19
180
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Postoperative ileus (POI) is a common complication after abdominal surgery, causing symptoms like nausea, vomiting, abdominal distension, and delayed passage of flatus and stool. Management remains challenging, with limited pharmacological options available. Prucalopride, a selective serotonin 5-HT4 receptor agonist, has shown promise in accelerating gastrointestinal recovery after surgery. However, the optimal timing and dosing for preventing POI remains unclear. Higher doses may provide more potent prokinetic effects in the postoperative setting. his study investigates if higher doses of prucalopride (4 mg) improve bowel function return and hospital stay in elective colorectal surgery patients compared to standard doses and placebo.
CONDITIONS
Official Title
Impact of Varying Doses of Prucalopride on Improving Gut Function Recovery After Elective Colorectal Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Undergoing elective colorectal surgery, including colectomy, rectal resection, and sigmoid resection
You will not qualify if you...
- Emergency surgery
- Total colectomy
- Creation of a stoma
- Pre-existing gastrointestinal disorders
- Severe renal or hepatic impairment
- Known hypersensitivity to prucalopride
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Matareya Hospital
Cairo, Egypt
Actively Recruiting
Research Team
A
Amir Samy Hanna
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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