Actively Recruiting
IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION
Led by Johann Wolfgang Goethe University Hospital · Updated on 2026-01-06
6000
Participants Needed
1
Research Sites
710 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Magnetic properties of myocardial tissue change in the presence of disease. This is detectable in the change of rate of magnetic relaxation, and measurable by T1 and T2 mapping using cardiovascular magnetic resonance (CMR). These markers provide novel quantifiable imaging measures for myocardial tissue characterisation. Despite similar principles, the measurements differ considerably between different sequences, vendors and field strengths, yielding a necessity to establish robust sequence-specific normal ranges, diagnostic accuracy, relationships with clinical characteristics, cardiovascular risk factors, routine cardiac imaging parameters, and prognosis. A further unknown relates to separation between healthy myocardium and subclinical disease in subgroups of patients with suspected cardiac involvement. Examples include patients with possible inflammation, such as in patients with a recent COVID-19 infection or vaccination. Anticipated recruitment of a total of 3000 subjects, with 1500 subjects per field strength (1.5 and 3.0 Tesla).
CONDITIONS
Official Title
IMPRoving Cardiovascular RiSk Stratification Using T1 Mapping in General populatION
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to provide informed consent
- 18 years of age and over
- No valid clinical indication for CMR and no known or clinically relevant cardiac disease
You will not qualify if you...
- Any accepted contraindications for a contrast-enhanced CMR study, following MRI safety guidelines and contrast agent instructions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Frankfurt
Frankfurt am Main, Hesse, Germany, Frankfurt am Main
Actively Recruiting
Research Team
V
Valentina O Puentmann
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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