Using Machine Learning Techniques to Predict MACE in Very Young Acute Coronary Syndrome Patients.
Pablo Juan-Salvadores, Cesar Veiga, Víctor Alfonso Jiménez Díaz...
https://pubmed.ncbi.nlm.nih.gov/35204511Actively Recruiting
Age: 18Years - 40Years
All Genders
ID06464042
Influence of Air Quality on the Development and Progression of Premature Coronary Artery Disease
Led by pablo Juan-Salvadores · Updated on 2024-06-18
4272
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
Sponsors
P
pablo Juan-Salvadores
Lead Sponsor
F
Fundacin Biomedica Galicia Sur
Collaborating Sponsor
AI-Summary
What this Trial Is About
Recent guidelines from the World Health Organization highlight the harmful effects of air pollution on health even at low levels. This research focuses on studying how environmental pollutants influence the early onset of coronary artery disease (CAD) in people aged 40 years or younger. It examines different types of CAD, including myocardial infarction and angina, and considers differences between men and women. The study is observational and compares two groups: patients aged 18 to 40 diagnosed with CAD and matched controls without coronary disease. Controls are selected from patients undergoing minor procedures or trauma treatment to ensure accurate medical histories and exposure data. The study investigates the impact of various pollutants such as particulate matter (PM2.5, PM10), gases, heavy metals, noise, and temperature on CAD development and progression. Participants' medical records will be reviewed over 15 years to assess pollutant exposure, incidence of major cardiovascular events, and prevalence of CAD by age and sex. Researchers will analyze data including environmental factors and clinical outcomes. The study tracks serious adverse events throughout this period to understand long-term effects. The total follow-up spans up to 15 years to monitor disease evolution and environmental influences.
CONDITIONS
Brief Title
Influence of Air Quality on the Development and Progression of Premature Coronary Artery Disease
Who Can Participate
Age: 18Years - 40Years
All Genders
Eligibility Criteria
You may qualify if you...
- Women and men between 18 and 40 years old with a diagnosis of coronary artery disease coded in their medical records in Galicia
- Women and men between 18 and 40 years old with no diagnosis or history of coronary artery disease coded in their medical records
You will not qualify if you...
- No postal code or primary care center assigned in medical records in Galicia
- Presence of non-ischemic coronary disease
- Serious condition affecting or decreasing life expectancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - Up to 15 years
Participants are observed to assess exposure to environmental pollutants and the development or progression of premature coronary artery disease.
Periodic visits depending on study protocol and participant status
Trial Site Locations
Total: 1 location
1
Hospital Álvaro Cunqueiro
Vigo, Pontevedra, Spain, 36211
Actively Recruiting
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Research Team
P
Pablo Juan-Salvadores, Pharma, PhD
V
Victor A Jiménez-Diaz, MD, MPH
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Coronary Artery Disease in Very Young Patients: Analysis of Risk Factors and Long-Term Follow-Up.
Pablo Juan-Salvadores, Víctor Alfonso Jiménez Díaz, Cristina Iglesia Carreño...
https://pubmed.ncbi.nlm.nih.gov/35323630Clinical Features and Long-Term Outcomes in Very Young Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries.
Pablo Juan-Salvadores, Víctor Alfonso Jiménez Díaz, Ana Rodríguez González de Araujo...
https://pubmed.ncbi.nlm.nih.gov/35990214Fine Particulate Air Pollution and Daily Mortality. A Nationwide Analysis in 272 Chinese Cities.
Renjie Chen, Peng Yin, Xia Meng...
https://pubmed.ncbi.nlm.nih.gov/28248546Short-term exposure to particulate matter (PM10 and PM2.5), nitrogen dioxide (NO2), and ozone (O3) and all-cause and cause-specific mortality: Systematic review and meta-analysis.
Pablo Orellano, Julieta Reynoso, Nancy Quaranta...
https://pubmed.ncbi.nlm.nih.gov/32590284Fine-Scale Air Pollution Models for Epidemiologic Research: Insights From Approaches Developed in the Multi-ethnic Study of Atherosclerosis and Air Pollution (MESA Air).
Kipruto Kirwa, Adam A Szpiro, Lianne Sheppard...
https://pubmed.ncbi.nlm.nih.gov/34086258Urban Air Pollution and Subclinical Atherosclerosis in Adolescents and Young Adults.
Szu-Ying Chen, Jing-Shiang Hwang, Chang-Chuan Chan...
https://pubmed.ncbi.nlm.nih.gov/35537887