Global cancer statistics, 2012.
Lindsey A Torre, Freddie Bray, Rebecca L Siegel...
https://pubmed.ncbi.nlm.nih.gov/25651787Actively Recruiting
Age: 18Years - 75Years
All Genders
ID03005132
Integrative Analysis of Human Glioblastoma Multiforme
Led by Shanghai 10th People's Hospital · Updated on 2016-12-29
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
S
Shanghai 10th People's Hospital
Lead Sponsor
J
Jilin University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting an integrative analysis of human glioblastoma multiforme (GBM) by studying the proteomes, transcriptomes, and genomic profiles of paired normal brain tissues, primary GBM tumors, and their matched metastases. This involves combining various data types, including whole exome sequencing and SNP array profiling, as well as analyzing existing genomic data from The Cancer Genome Atlas (TCGA). The study collects samples from GBM patients, including normal brain tissue, primary tumor tissue, and metastasis tissue. From these samples, investigators extract total protein, DNA, and RNA to perform detailed molecular analyses and conduct integrated proteogenomic evaluations. This is an observational study without intervention or treatment administration. Participants undergo tissue sampling and molecular data collection for research purposes. The main outcome measured is 5-year overall survival, with secondary outcomes including 5-year and 10-year disease-free survival and overall survival. The study spans multiple years to assess long-term outcomes. Participants will be monitored according to the study schedule, but no treatment is provided as part of this trial.
CONDITIONS
Brief Title
Integrative Analysis of Human Glioblastoma Multiforme
Who Can Participate
Age: 18Years - 75Years
All Genders
Eligibility Criteria
You may qualify if you...
- Age 75 years or younger with confirmed glioblastoma multiforme
- No severe major organ dysfunction
- World Health Organization (WHO) performance status of 0 or 1
- No prior cancer chemotherapy
You will not qualify if you...
- Age 76 years or older
- Severe major organ dysfunction
- World Health Organization (WHO) performance status greater than 1
- Prior cancer chemotherapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Single timepoint
Participants provide tissue samples including normal brain tissue, GBM tissues, and metastasis tissues for integrated proteogenomic analyses.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 10 years
Participants are observed for up to 10 years to assess overall and disease-free survival.
Periodic visits depending on follow-up schedule
Trial Site Locations
Total: 1 location
1
Shanghai Tenth People's Hospital
Shanghai, Shanghai Municipality, China, 200072
Actively Recruiting
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Research Team
D
Da Fu, PhD
Y
Yushui Ma, BS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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