Actively Recruiting
Interaction Between Gut Microbiota and TKIs in Defining the Clinical Outcomes of Patients With CML
Led by Carmen Fava · Updated on 2024-12-09
100
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
Sponsors
C
Carmen Fava
Lead Sponsor
P
Pfizer
Collaborating Sponsor
AI-Summary
What this Trial Is About
Gut microbiome (GM) is acquiring increasing importance in human health and disease. GM influences hematopoiesis and immune cells types differentiation. Patients with cancer are characterized by dysbiosis and compromised immunity. In the case of Chronic Myeloid Leukemia (CML), treatment with Tyrosine Kinase Inhibitors (TKIs) restores immunosurveillance; in particular deep molecular response (DMR) is associated with increased levels of NK and CD8+ Tcells. There is no literature on the effects of GM on CML outcomes. This project aims to identify a microbial signature associated with a higher probability of achieving DMR.
CONDITIONS
Official Title
Interaction Between Gut Microbiota and TKIs in Defining the Clinical Outcomes of Patients With CML
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years old
- Diagnosed with Chronic Myeloid Leukemia
- Any stage of Chronic Myeloid Leukemia
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
AO Ordine Mauriziano di Torino
Torino, Italy, 10128
Actively Recruiting
Research Team
C
Carmen Fava
CONTACT
V
Valentina Bonuomo
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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