Actively Recruiting
Interest of the 7 Tesla MRI in the Diagnosis of Post-concussion Syndromes Among Patients With Mild Traumatic Brain Injury
Led by Poitiers University Hospital · Updated on 2026-05-22
100
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients who have experienced a mild traumatic brain injury (MTBI) and subsequently developed post-concussion syndrome (PCS). This study aims to evaluate how well a seven tesla MRI detects diffuse axonal lesions, which are linked to PCS symptoms like dizziness, headache, and memory problems. These lesions are often missed by standard imaging and may explain persistent symptoms in some patients. This is a prospective, longitudinal, interventional study conducted at a single center to assess diagnostic performance at seven days after injury. Participants will receive a seven tesla brain MRI seven days after their mild head injury and onset of PCS symptoms. This advanced MRI technique is being assessed for its ability to identify brain lesions that are not visible on regular imaging. The study focuses on patients admitted to emergency care for MTBI who develop PCS. The MRI is scheduled as a single diagnostic scan performed at day seven post-injury. During the study, researchers will measure how accurately the 7T MRI detects post-concussion syndrome and correlate these findings with blood tests measuring the S100b protein, quality of life assessments, neuropsychological tests, and other MRI sequences like diffusion tensor imaging. Follow-up evaluations will occur up to 12 months after injury to monitor cognitive function, anxiety, depression, and lesion presence. The study duration for participants includes imaging at day seven and multiple follow-ups at months 3, 6, and 12 to assess long-term outcomes.
CONDITIONS
Brief Title
Interest of the 7 Tesla MRI in the Diagnosis of Post-concussion Syndromes Among Patients With Mild Traumatic Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Mild traumatic brain injury with Glasgow Coma Scale between 13 and 15 and indication for scan
- Ability to undergo an MRI scan at 7 days after injury
- Patient able to attend MRI appointment at day 7
- Provided free and informed consent to participate
- No guardianship, curatorship, or subordination relationship
You will not qualify if you...
- Patient not hospitalized for head trauma
- Unable to attend MRI at day 7
- Contraindications for MRI (e.g. claustrophobia, BMI > 40)
- Previous emergency consultation for head trauma requiring imaging
- Psychiatric disorders including bipolar disorder, panic disorder, depression, schizophrenia
- Already enrolled in the study
- History of brain tumor or neurosurgery
- Untreated or poorly treated chronic vertigo or migraines
- Claustrophobia
- BMI greater than 40
- Refusal to consent
- No social welfare coverage or inability to benefit from it
- Enhanced protection status (minors under 18, legal restrictions, living in health or social establishments, adults under legal protection)
- Pregnant or nursing women
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo a 7 Tesla brain MRI at day 7 to detect diffuse axonal lesions associated with post-concussion syndrome after mild traumatic brain injury.
1 visit (in-person) at day 7
Duration - Up to 12 months
Participants are monitored over time to assess the evolution of post-concussion syndrome symptoms, quality of life, and correlation with MRI findings and neuropsychological tests.
Visits at Month 3, Month 6, and Month 12
Trial Site Locations
Total: 1 location
1
CHU Poitiers
Poitiers, France, 86000
Actively Recruiting
Research Team
J
Jeremy GUENEZAN, Dr
M
Marika SAVATIER, Dr
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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