Using 7 Tesla MRI to Detect Post-Concussion Syndrome in Adults with Mild Traumatic Brain Injury

What this Trial Is About

Researchers are studying patients who have experienced a mild traumatic brain injury MTBI and subsequently developed post-concussion syndrome PCS. This study aims to evaluate how well a seven tesla MRI detects diffuse axonal lesions, which are linked to PCS symptoms like dizziness, headache, and memory problems. These lesions are often missed by standard imaging and may explain persistent symptoms in some patients. This is a prospective, longitudinal, interventional study conducted at a single center to assess diagnostic performance at seven days after injury. Participants will receive a seven tesla brain MRI seven days after their mild head injury and onset of PCS symptoms. This advanced MRI technique is being assessed for its ability to identify brain lesions that are not visible on regular imaging. The study focuses on patients admitted to emergency care for MTBI who develop PCS. The MRI is scheduled as a single diagnostic scan performed at day seven post-injury. During the study, researchers will measure how accurately the 7T MRI detects post-concussion syndrome and correlate these findings with blood tests measuring the S100b protein, quality of life assessments, neuropsychological tests, and other MRI sequences like diffusion tensor imaging. Follow-up evaluations will occur up to 12 months after injury to monitor cognitive function, anxiety, depression, and lesion presence. The study duration for participants includes imaging at day seven and multiple follow-ups at months 3, 6, and 12 to assess long-term outcomes.

Interest of the 7 Tesla MRI in the Diagnosis of Post-concussion Syndromes Among Patients With Mild Traumatic Brain Injury